>How does the whole NIATONIN thing work?

Telegram and FR | September 9, 2021 | Dr. Dmitry Kats (interpreted)

[numberonepal]

How does the whole NIATONIN thing work?

LAYMAN'S VERSION

Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.

The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.

The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.

The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.

THE DR KATS LAYMAN'S VERSION
(edited for clarity - English is not his first language)

Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.

It's literally like the virus and covid pathogenesis, just slower.

These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.

It's a feasting ground for them (viruses).

Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.

They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.

Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/

The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.

The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.

Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.

As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.

Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.

This leaves ACE2 downregulated, and happens especially in the intestines/colon.

This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.

Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.

So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).

It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.

Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/

What To Buy

NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…

MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…

Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…

DOSING

This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.

HOW TO FLOW CHART

[EEGator]

That is a lot of melatonin..

[Wuli]

Way toooooo complicated of a diagram for a layman to understand and follow.

The diagram needs to be reduced to a question and answer description.

[corkoman]

Quackery - must be obfuscated with lots of specious words and dopey diagrams or others would see all the feathers.

[numberonepal]

Quackery

Prove it.

[numberonepal]

Just follow the arrows. That is as simple as I can make it.

[sauropod]

.

[ConservativeMind]

Interesting read, but you provided exactly zero documentation about melatonin and niacin's influence from studies or anything outside of what this unknown person claims, and in a foreign tongue that may be improperly translated.

150 mg of melatonin a day and 6,000 mg of flush niacin a day is crazy, without better documentation than what you provided.

[numberonepal]

That is a lot of melatonin..

In the sense of taking the low advertised doses - yes it does seem like a lot. However, the niacin serves as a fantastic barometer as to how much melatonin you need. Try not to think of it in terms of x amount of melatonin puts me to sleep. When taken with niacin, it is used up. See the little graphic at the beginning of the post. I am up to 100mg melatonin with 1000mg niacin 3x per day and I'm not a zombie.

[Myrddin]

Thanks for taking the time to capture the info and update for American English. I've interacted with Dmitry on Twitter until a twitter-bot was employed to cause his account to be suspended. He's on Telegram, but that format isn't well organized.

[EEGator]

I might try the mix. You’re taking around 33 times the normal “sleep” dose.

I’ll start off far lighter. Just melatonin by itself gives me night terrors.

[numberonepal]

150 mg of melatonin a day and 6,000 mg of flush niacin a day is crazy, without better documentation than what you provided.

That's because most view melatonin as a sleep aid. This has nothing to do with that. Yes, it could use more sauce. The papers are scattered and this is coming from an epidemiologist who has put it all together. He provides sources, but I simply have not put them all together yet. If you'd like to point out any errors, I'm listening. Further, I did not translate from a foreign tongue. I edited his English explanation to be more easily read. Punctuation is not Dr. Kats strong point.

[numberonepal]

He's on Telegram, but that format isn't well organized.

Amen. It's hard to find your place if you comment or read a reply. Needs work if you ask me.

[Myrddin]

My lunch time regimen is 5 grams of glutamine (powder) in water, 10 mg chewable melatonin, then 10 minutes later 500 mg NAC and 500 mg flush niacin. My wife couldn't tolerate 500 mg niacin. She went beyond a flush to having a raised rash all over. She has worked up from 100 mg niacin to 200 mg now and doing fine. As a police/fire/EMS dispatcher, her circadian rhythms and melatonin cycles are pretty messed up.

[aMorePerfectUnion]

Sounds like the empty vaxx list of ingedients…

[numberonepal]

I might try the mix. You’re taking around 33 times the normal “sleep” dose.

I had to break that dogma of thinking of melatonin as a sleep aid. That's not what this is about. This is about pushing out inflammation. When taking the melatonin chased with niacin, the melatonin is all used up. You can start off lighter as that may be what YOU need. That's the point - everyone is different. You have to find your sweet spot (ratio) where there is no flush. I recommend starting low on niacin and high on melatonin to avoid flush. I've grown to like a little bit of flush, but it can be scary to some - especially the first time. I was like WHEW! I'm on fire on the inside. It is perfectly safe, however.

[CJ Wolf]

Does this help with Arthritis?

[numberonepal]

I’m hitting 600mg of NAC twice a day with my niacin dose. It’s ok to mix them together in water.

[EEGator]

The flush wouldn’t scare me.

I’ve taken some pre workout drinks that did however.
Heart pounding, skin itches, goose bumps, and the scalp tingles.

[Mr. K]

I understood it perfectly

You can’t think of the entire thing at once- you just follow it one day at a time.

Do you get a flush? yes or no? follow the next arrows to determine if you need more niacin or more melatonin.

The ‘first dose’ is a special case - Niacin can scare the crap out of you if you don’t know what is going to happen- you get all hot and turn red- it only lasts about 15 minutes though. The next day you will feel amazing.