He surely did. One of the times he had gotten severely wounded and had to recuperate for some months, he was holed up in Balkh (impressive site to the present day) for the winter; as spring arrived, so did the massive reinforcements, mostly Greeks from the conquered/liberated Persian areas and the Greek homeland. The largest Greek force ever assembled up to that time (hmm, perhaps *ever*) was divided into four parts and sent up into the four major river valleys, kicking the crap out of everyone and everything they found. By the end of that campaign season, Big Al had established the basis for the later Hellenistic kingdom of Bactria (Balkh is the city of Bactria).
And he wasn’t done. He finally stopped his advance just over the Indus River.
IIRC, Big Al did not want to stop but his army refused to go any further. Not the first time his army “went on strike” but his time the army really meant it. “Enough! Lead us back to Greece (Macedonia)”. Big Al reluctantly agreed and then choose the hardest possible route (thru the desert) to punish his army for there refusal to continue.