Yeah, if they went by land, it would have been 5 million years ago, and no one will buy that -- but accepting pre-Sapiens seafaring is the other barrel of a two-ended handgun to the Out-of-Africa jokers.
If there was ever a passage ancient people could have used my guess would be in the Strait of Sicily, say, between Cape Bon, Tunisia and Sicily.
There have been proposals to build an undersea tunnel in that area so it can’t be too deep.