No.
In fact, this is where they make the MOST money.
The enterprise is nothing more than the volume license for the client they sell to most corporations with more than 100 workstations.
So anyone using KMS, MAK or other volume activation methods use the Enterprise version--in other words, the most sold.
If you want to use AppLocker, DirectAccess, BranchCache, managed image deployment and a dozen other large-scale technologies, you'll need the Enterprise version.
Most enterprises will be upgrading to Windows 10 Enterprise version about the time that Microsoft releases Windows 11. . . That's when they will feel safe about doing it.