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A Study to Evaluate the Effect of ASP1941 in Adult Patients With Type 2 Diabetes Mellitus
bert/ Astellas Pharma Inc ^ | 05/09/10 | bert

Posted on 05/09/2010 10:40:42 AM PDT by bert

I am posting my thoughts on my participation in a drug trial for a new drug to treat type II diabetes. I have been diagnosed for 6 years but it has been in the last year that my A1C and blood glucose number have crept up to 7.1 and fasting level of >140

My primary care doctor suggested me as a possible participant because my numbers have recently crept above 140 and 7.1. He is a family practice doctor and a member of a medical group with a specialized team that provides care for diabetes patients. The team consists of several nurses and lab techs working under a physician. Additionally, there is a clinical research team that allows group physicians to participate in various research projects in addition to their normal practice. All the above are combined in the trial involving me as a participant.

The details of the study can be found on the following link

http://clinicaltrials.gov/ct2/show/NCT01071850?term=diabetes&rcv_d=14


TOPICS: Health/Medicine
KEYWORDS: asp1941; diabetes; diabetestypeii; dibetestype2; drugtest
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To: grame

I was not on medication before the trial. Diet seemed to have no significant effect. Exercise was the factor that made the difference.

Age is the factor that seems to have has changed


21 posted on 05/09/2010 6:47:59 PM PDT by bert (K.E. N.P. +12 . Ostracize Democrats. There can be no Democrat friends.)
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To: bert

my husband like you had a ‘high’ low point, but with much work we have gotten it down into the 60-70 range. But not without some too high highs and too low lows.


22 posted on 05/09/2010 6:55:59 PM PDT by grame (May you know more of the love of God Almighty in the coming year)
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To: bert; austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; ...
Bert, thanks for the post & ping. It's a numbers game. Some years ago the cut off for fasting plasma glucose was reduced to 126 from 140.

How are diabetes and pre-diabetes diagnosed?

FReepmail me if you want on or off the diabetes ping list.

23 posted on 05/09/2010 9:12:53 PM PDT by neverdem (Xin loi minh oi)
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To: bert

“In modern medicine, numbers are everything. Determining and interpreting members and their variance from established norms is the name of the game. Blood tests are a primary, perhaps the primary source of numbers.”

Unless it does something other than just lower the numbers, then I am not interested. This obsession with numbers has not proven to affect the long term complications of diabetes. People are treating the symptoms and not the undelying disease. Do not be lulled into a false sense of security.


24 posted on 05/09/2010 9:16:28 PM PDT by Pining_4_TX
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To: bert
I hope this is not boring the group

It's not.

25 posted on 05/09/2010 9:43:10 PM PDT by null and void (We are now in day 472 of our national holiday from reality. - 0bama really isn't one of US.)
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To: bert
They pay me $40 per visit plus breakfast

They feed you?

I am soooo there!

26 posted on 05/09/2010 9:44:45 PM PDT by null and void (We are now in day 472 of our national holiday from reality. - 0bama really isn't one of US.)
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To: verity; ASOC

Where did ASOC say his brother had diabetes?


27 posted on 05/09/2010 9:46:32 PM PDT by null and void (We are now in day 472 of our national holiday from reality. - 0bama really isn't one of US.)
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To: neverdem
thanks, for the ping.

28 posted on 05/09/2010 10:58:36 PM PDT by skinkinthegrass (Zer0 to the voters: "Here's my DeathCARE Plan"...now....just die (quicky), please. :^)
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To: neverdem; Pining_4_TX

.....Some years ago the cut off for fasting plasma glucose was reduced to 126 from 140....

The difference between 149 and 126 is 14. Fourteen is a strange number except for the fact it is 10% of 140. The medical group studying the numbers concluded a reduction in the threshold was in order and agreed on a 10% reduction. It was some what arbitrary decision.

Realizing this fact I became skeptical of the whole process. Some of that skepticism remains but I have concluded that just because the diabetic condition is not completely understood, erring on the side of caution might save your eyesight.


29 posted on 05/10/2010 4:33:59 AM PDT by bert (K.E. N.P. +12 . Ostracize Democrats. There can be no Democrat friends.)
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To: bert
Thanks for the ping and for the info, bert. I was diagnosed pre-diabetic about ten years ago and I don't know exactly when they decided I had Type II officially. I'm have an auto-immune disease. I took high doses of steroids for several years and they think that is what caused the diabetes. I also have high triglycerides, etc.

About a year ago, I decided to see an endocrinologist because I felt that I needed the accountability. Having the other health problems leaves me severely fatigued sometimes and I tend to go with what is easy (ie, eat whatever is easiest). I am happy to report that I have been able to get my H1C from 8.0 to 6.8. Would like to see that even lower. I take Janumet and Actos, eat almost no sugar, potatoes, rice, or flour products.

30 posted on 05/10/2010 5:33:21 AM PDT by Calm_Cool_and_Elected (I'm a Republican and I own a cat.)
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To: null and void
"Some years ago,, my brother got an 'experimental' treatment - which cured him."

1. Since this tread is about diabetes, it is natural to assume the subject was diabetes.
2. Since ASOC did not correct my assumption, I can further assume that that my assumption may be more than an assumption. ;-)

31 posted on 05/10/2010 7:00:00 AM PDT by verity (Obama Lies - Obongo must go!)
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To: verity

Or he’s off line...

Since this thread is also about being a guinea pig, I’m not certain that this particular guinea pig-hood is diabetes related, although I agree that’s the way to bet!


32 posted on 05/10/2010 8:30:08 AM PDT by null and void (We are now in day 473 of our national holiday from reality. - 0bama really isn't one of US.)
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To: verity

Also, bariatric surgery seems to “cure” type II in many patients, although the phrase used is to put it “in remission”.

As you will doubtless recall, no one was ever “cured of cancer” (indeed, it was illegal to even say you could cure cancer).

With more modern treatments cancer could be put “into remission” for years or decades or the remaining full natural life, but never cured!


33 posted on 05/10/2010 8:37:02 AM PDT by null and void (We are now in day 473 of our national holiday from reality. - 0bama really isn't one of US.)
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To: MrLee

I turned it around ten years ago with 6 months of holding my carb intake below 30.

I then gradually went back to the Standard America Diet (SAD) and gradually my symptoms came back. PCOS, a gradually elevating A1C, weight gain on a low-calorie diet.

This time my challenges are greater as I now also have hypothyroidism. A person with hypothyroidism cannot take their carbs to less than 40 or they will begin to create reverse T3 instead of T3.

I’m one month in, holding steady between 40-50g of carbs. I’ll get my physical in three months.

So far the biggest difference is that I feel better than I have in *years*! I’ve lost 15 pounds and I’m averaging a little more than a pound a week now that the initial water weight loss has stopped.

It’s been a gradual process adjusting to my new diet and I’m learning more about my body every day.


34 posted on 05/10/2010 10:39:18 AM PDT by Marie (Obama seems to think that Jerusalem has been the capital of Israel since Camp David, not King David)
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To: Marie

I forget to add that I’m also taking Metforamin.


35 posted on 05/10/2010 10:42:53 AM PDT by Marie (Obama seems to think that Jerusalem has been the capital of Israel since Camp David, not King David)
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To: neverdem
In my experience, there never seems to be a consensus from one MD to another as to what the true 'cutoff' is for plasma glucose readings. I've lost almost 20 lbs. since the holidays, I take cinnamon as a supplement, but I just stuck myself and dialed in at 152, three hours after having a small cup of chicken soup. The tale shall be told when my A1C tests comes back after my checkup next month. I hope I don't have to back on Glucovance again. Then again, I have the head cold from Hell, and that always skews my stick tests. Prednisone is another one that'll shoot readings into orbit.

"But know this, that in the last days perilous times will come: for men will be lovers of themselves, lovers of money, boasters, proud, blasphemers, disobedient to parents, unthankful, unholy, unloving, unforgiving, slanderers, without self-control, brutal, despisers of good, traitors, headstrong, haughty, lovers of pleasure rather than lovers of God, having a form of godliness but denying its power. And from such people turn away, for his name is Obama."

36 posted on 05/10/2010 2:37:44 PM PDT by Viking2002
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