An exterminator is probably the only way to go - professional - and it is not cheap. And not easy for the homeowner either - everything must be washed, dryer dried, in the summer some stuff can be sealed in plastic bags and left in a hot car - all drawers emptied and treated, perhaps new box springs, headboards, etc.
A relative (who does stay in hotels every several months) went through it last year and it was brutal.
On Amazon you can find an Ozone generator which ozone oxygen. They cost less than $150. Hugs hate ozone oxygen Abe it will also purified the air of bacteria, fungus, virus and mites. I have several for different areas.
I just keep on wondering how such great masses of the bugs aggregate. People don’t have that much blood to share. They’d bleed to death. They are not garbage eaters, like cockroaches.