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I'm afraid you have missed the entire syllogism Paul was offering. Let's get the passage in context, first, for Paul was addressing Jews confronting Christ and The Way. The mindset of Jews was the Law of Moses, and the sacrifice made once per year to take away the sins of the entire people. Shadowing that, Paul refers to how despising that sacrifice meant the individual's sin remained and God can take vengeance upon such an one who would despise the sacrifice (the one who tramples the Grace of God is without a means to have sin erased):

Heb 10
26 For if we sin wilfully after that we have received the knowledge of the truth, there remaineth no more sacrifice for sins,
27 But a certain fearful looking for of judgment and fiery indignation, which shall devour the adversaries.
28 He that despised Moses' law died without mercy under two or three witnesses:
29 Of how much sorer punishment, suppose ye, shall he be thought worthy, who hath trodden under foot the Son of God, and hath counted the blood of the covenant, wherewith he was sanctified, an unholy thing, and hath done despite unto the Spirit of grace?
30 For we know him that hath said, Vengeance belongeth unto me, I will recompense, saith the Lord. And again, The Lord shall judge his people. [[ Deut 32:35,36 ]]

You might notice immediately that Paul refers to one who has received THE KNOWLEDGE of the Truth. Paul does not refer to one who has received The Earnest of the inheritance, the Holy Spirit, merely the knowledge of that truth that God wipes the soul clean and then comes to be there, indwelling the believer.

In verse twenty-nine, Paul then applies the lesson of the sacrifice done once for all Israel to the Supreme sacrifice of Christ as The Lamb of God, sacrificed once and not to be repeated. Paul is actually pointing to the assurance that such an sacrifice is far superior to the once each year of Hebrew tradition! And he goes on to assert that if an man is sanctified by such a sacrifice and then despises that sanctification, there would not be a repeat of the sacrifice and therefore damnation is absolutely guaranteed.

Now, put that lesson from Paul beside what he also taught about a Grace where God is faithful and just to forgive us our sins, AFTER WE HAVE RECEIVED THE HOLY SPIRIT GIFT of God indwelling us. What Paul is emphasizing for the Hebrews confronting the reality of Messiah sacrificed as the Lamb of God Who takes away the sin of the world is the fact that no repetition is required nor any repetition of the sacrifice possible, for Jesus died once for all.

If you have read your Bible for content you will recall that Paul on many occasions wrote that therefore there is now no condemnation to those who are in Christ Jesus. That no condemnation is absolute, by the Promise of God being an absolute guarantee, and believers are not appointed to wrath but to salvation from the hour of the testing to come. There is no equivocation in those many passages where Paul cites the absoluteness of God's Promise to save. There is no thing that a Sanctified believer can commit that separates him from the Love and therefore the Promise of God in you, the Hope of Glory. [[ Hebrews 7:26 ; Romans 8:35 and 39]]

Do you believe God is able to prevent your destruction, spiritually? ... John 10:28 And I give unto them eternal life; and they shall never perish, neither shall any man pluck them out of my hand. John 10:29 My Father, which gave them me, is greater than all; and no man is able to pluck them out of my Father's hand.

Sanctified means washed clean and being indwelt in the Age of The Church. In the age of the law of Moses and the once per year sacrifice by which faith in that sacrifice cleansed, sanctification was done over and over. Paul's message is 'Jesus died once for the all and there is now no other sacrifice to come so this cleansing is absolute such that (see the two verse above) no man nor any enemy can remove one held by those two hands of God. And that includes you, you are not more powerful than God's Grace, so you cannot, once sanctified, turn on that indwelling and wriggle out of His Hands. When God says NO MAN that includes you, too.

Meant to include you in the ping ...

I did NOT miss anything!

Philippians 2:12-Therefore, my beloved, as you have always obeyed, so now, not only as in my presence but much more in my absence, work out your own salvation with fear and trembling;

2 Cor 5:10-For we must all appear before the judgment seat of Christ, so that each one may receive good or evil, according to what he has done in the body.

Rom 2:6 - For he will render to every man according to his works:

Rom 11:22, Note then the kindness and the severity of God: severity toward those who have fallen, but God’s kindness to you, provided you continue in his kindness; otherwise you too will be cut off.