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The Biblical explanation to your verse (in the same chapter if you bother to keep reading)...

John 6:58 “This is that bread which came down from heaven: NOT as your fathers did eat manna, and are dead: he that eateth of this bread shall live for ever.”

Jesus wasn’t talking about a physical eating of his “flesh” like their ancestors did with manna (like some of the people initially thought). This “eating” is belief through faith.

Peace.

Looks to me that Christ totally affirms the real presence when you read farther down in the chapter. Just as all of the early church fathers believed. Protestant innovation comes about 1400 years later in rebellion against Christ's church. Rebellion does not come from Christ, it has another source.

51 I myself am the living bread that has come down from heaven. 52 If anyone eats of this bread, he shall live for ever. And now, what is this bread which I am to give? It is my flesh, given for the life of the world.

54 Whereupon Jesus said to them, Believe me when I tell you this; you can have no life in yourselves, unless you eat the flesh of the Son of Man, and drink his blood. 55 The man who eats my flesh and drinks my blood enjoys eternal life, and I will raise him up at the last day. 56 My flesh is real food, my blood is real drink. 57 He who eats my flesh, and drinks my blood, lives continually in me, and I in him. 58 As I live because of the Father, the living Father who has sent me, so he who eats me will live, in his turn, because of me.