SMALLPOX AND FORCED VACCINATION: WHAT EVERY AMERICAN NEEDS TO KNOW

The terrorist attacks on New York City and Washington, D.C. on September 11, 2001 and the subsequent threats of biological warfare against US citizens have prompted calls by public health officials to prepare for mass vaccination campaigns for anthrax and smallpox.^1,2 National vaccination programs targeting civilians, including children, are being proposed in model state legislation that would give public health officials the power to use the state militia to enforce vaccination during state-declared health emergencies.^3,4 While it is critical for the US to have a sound, workable plan to respond to an act of bioterrorism, as well as enough safe and effective vaccines stockpiled for every American who wants to use them, there are legitimate concerns about a plan which forces citizens to use vaccines without their voluntary, informed consent.

All mass vaccination campaigns result in casualties because every vaccine, like every drug, carries an inherent risk of injury or death.^5,6,7,8,9 Some individuals are genetically or biologically more vulnerable to vaccine reactions than others,¹⁰ but there are few reliable biomarkers to predict who they are^5,6,7,8,9 which is why legally protecting the informed consent rights of all citizens becomes a moral imperative. The human right to be fully informed about all known and unknown risks, as well as benefits, of any medical intervention and make a voluntary decision about whether to take the risk, has been the centerpiece of bioethics ever since the Nuremberg Code was adopted after World War II ¹¹ and the doctrine of informed consent was introduced into U.S. case law in 1957.¹²

In evaluating the potential risk of a bioterrorism attack with real, as well as unpredictable, risks of exposing large numbers of children and adults to a prophylactic mass vaccination program for smallpox, some health officials have already concluded that the risks of mass vaccination outweigh the theoretical benefits.^13,14,15 However, even in the event of a proven biological weapons assault and smallpox outbreak, sacrifice of the informed consent ethic would result in state-forced vaccine-induced injury and death of a biologically vulnerable minority in service to the majority, posing serious constitutional and moral questions.

Although there have been suggestions that federal vaccine testing regulations should be curtailed in an effort to get a national supply of smallpox vaccine produced quickly,^16,17 no mass vaccination campaign should be initiated without sound scientific evidence proving the vaccines to be used are safe and effective in protecting against an organism that may be used in a bioterrorism attack. This is particularly important if the organism, such as the smallpox virus, may have been genetically engineered to be vaccine and treatment resistant.¹⁸Untested vaccines have the potential to give the illusion of safety and efficacy to the public when, in fact, they may cause far greater harm and be far less effective than predicted. The old live vaccinia virus vaccine for smallpox was never tested for safety or efficacy in controlled trials prior to mandates^19,20 and it may have caused more reactions, injuries and deaths than any vaccine ever used by humans on a mass basis. Those recently vaccinated become infected with vaccinia virus and can transmit the virus to others, leading to injury and death for some.^{13,20,21,22,23,24,25} Unless the old vaccine for smallpox or a newly formulated vaccine is fully tested for safety and efficacy before being released for public use, legally and ethically the vaccine would have to be considered experimental and the mandated use of it a state-enforced national scientific experiment.

Public Health Different Today: Scientific evaluation of the mass use of any new vaccine must be viewed in context with the other vaccines Americans are getting today and in consideration of the general health of different segments of our population. The most significant difference between the health of the U.S. population today compared to 1971, when routine vaccination for smallpox was halted in America, is that the numbers of Americans suffering with autoimmune and neurological disorders has increased significantly.^21,26,27

In the past three decades, the numbers of children and young adults with asthma, learning disabilities and attention deficit hyperactivity disorder (ADHD) have doubled; diabetes has tripled; and autism has increased 200 to 600 percent in nearly every state.^{29,30, 31,32,33,34,35,36,37,38} Live vaccinia virus vaccine for smallpox, for example, would be given to children already receiving 37 doses of 11 other live virus and killed bacterial vaccines, including diphtheria, pertussis, tetanus (DTaP), polio, measles, mumps, rubella (MMR), haemophilus influenzae B, hepatitis B, chicken pox, and pneumococcal vaccines.³⁹ In 1971, most American children were only receiving DPT, polio, measles and rubella vaccines.⁴⁰

In addition, today there are many more adults suffering with HIV, lupus,⁴¹ herpes⁴² and other diseases affecting the immune system. Without appropriate safety studies evaluating the risks of an old or a new vaccine in the real world of today, there is no reliable way to predict the potential negative impact on the health of children and adults, especially on the tens of millions of Americans already suffering with chronic autoimmune and neurological disorders.

Biological warfare is not a new phenomenon. History is full of examples of warring factions trying to weaken each other’s troops or civilian populations by making them sick. From the ancient Greeks and Romans, who polluted the water supplies of their enemies with dead animals, to warriors in medieval times who catapulted corpses of people infected with bubonic plague into the castles of their enemies, to European conquerors who came to the New World and used smallpox contaminated blankets to kill native Indians with no natural immunity to smallpox, there is a long history of man using disease as a weapon. ⁴³

Modern biological weapons using lethal microorganisms were developed in the 1930’s by Japanese scientists, including aerosolized anthrax that was designed to be used in a specially designed fragmentation bomb. US and British scientists developed biological weapons during World War II using anthrax, botulinum toxin, encephalitis virus, staph enterotoxin and other deadly organisms. Even though the US has had biological weapons capability, the US has never used biological weapons on any nation and, since the Biological Weapons Convention in 1972, has supported a worldwide ban on development and use of biological weapons.

There is evidence, however, that other nations have not stopped making biological weapons and that the Soviet Union, in particular, may have weaponized smallpox virus after 1972 in large quantities and that some of the virus may have been supplied to other countries such as Iraq, North Korea and China. There are still outstanding questions about whether Soviet scientists succeeded in making the smallpox virus a more lethal weapon by genetically engineering it so that any vaccine or drug would be ineffective. ^1,18

Smallpox is a highly contagious, serious disease caused by the variola virus, a double stranded DNA virus which belongs to the genus orthopoxvirus that includes cowpox, monkeypox, and vaccinia. Poxviruses primarily affect the skin and cause disease in both humans (smallpox) and animals (swinepox, camelpox, sheeppox, goatpox, fowlpox).¹⁹

History: The first recorded cases of smallpox were in Asia in the first century A.D. but there is evidence the disease was present in China, India and Africa before that time. Smallpox was rarely seen in Europe until the Crusades, when Crusaders invaded the Holy Land during the Middle Ages and brought the disease back home with them. The Americas did not see smallpox until the Spanish invaders brought the disease to native Indian populations, who had no experience with the virus at all, which resulted in high mortality and significant destruction of tribes. In 18^th century England, smallpox caused one in 10 deaths and was the leading cause of death in children.^43,46

After worldwide mass vaccination campaigns in the 20^th century, in 1979 the World Health Organization declared wild smallpox virus eradicated from the earth. The only remaining smallpox virus at that time was reported to exist in secure labs in the Soviet Union and the United States. However, since then, there have been reports that Soviet scientists developed the capacity to produce large quantities of the virus modified to survive delivery by missile warhead and that some of these stocks were supplied to countries hostile to the US.⁴⁷ In addition, there is the possibility that the smallpox virus has been genetically or otherwise biologically altered to make it an even more lethal bioterrorism weapon, which may limit the effectiveness of the vaccinia virus vaccine used to prevent smallpox in the past.^18,48

Viability As A Bioterrorist Weapon: Variola is a relatively stable virus in the natural environment and may retain its infectivity for as long as 24 to 48 hours if it is aerosolized and not exposed to sunlight or ultraviolet light. ⁴⁹ There are several delivery routes that have been discussed if smallpox were to be used as a bioterrorist weapon to cause large numbers of infections in a population: release of the virus into a building, subway or airplane ventilation system or an area-wide drop of the virus by a plane or missile. Each of these theoretical scenarios requires that the terrorists: (1) have succeeded in obtaining the smallpox virus from one of the official laboratory storage facilities in the US or Russia or from a country which has secretly obtained the virus; (2) have the technical expertise and laboratory facilities to culture and maintain the viability of the virus; (3) have the ability to transport the virus in liquid or powder form without destroying its effectiveness; (4) have the technology to deliver it to large numbers of susceptible people. ^45,50

Some have hypothesized that several “volunteer” infected carriers could silently transmit the disease,¹⁸ perhaps in large cities during the first week of the contagious period before the characteristic smallpox lesions appeared on their faces and limbs. Theoretically, this could happen although it would not be as effective as delivery of the organism to large numbers of people in a wide area. Still, even one person carrying smallpox could cause others to become infected who, in turn, could infect others. Reportedly, in 1970 a single smallpox infected man returning to Germany from Pakistan caused the direct or indirect infection of 19 others in a German hospital.⁵¹ In 1970, virtually everyone in Europe and the U.S. had been vaccinated against smallpox.

Variola Virus: The variola virus which causes smallpox is an orthopoxvirus and has not been documented to infect animals or insects. Cowpox, monkey pox and vaccinia are the three other orthopoxviruses and all three of these viruses can cause disease in both animals and humans.⁴⁹

Two Kinds of Smallpox: There are two kinds of smallpox: variola minor and variola major. Variola minor causes a milder case of the disease resulting in a case-fatality ratio of less than one percent. Variola major is much more serious with a case fatality of between 20 and 30 percent. The variola virus causing both variations of smallpox are biologically and immunologically indistinguishable from each other in the laboratory and a mild case of variola major can look like a case of variola minor. Endemic variola major was eradicated from the US in 1926 and variola minor disappeared from the US in the 1940’s.^19,22

Infection and Contagion: According to the Working Group on Civilian Biodefense, “Historically, the rapidity of smallpox contagion was generally slower than for such diseases as measles and chickenpox. Patients spread smallpox primarily to household members and friends; large outbreaks in schools, for example, were uncommon.”⁴⁹

Face-to-face contact with an infected person is usually required to transmit smallpox, which is spread from one person to another through nasal secretions and saliva by coughing and sneezing.⁵² A person usually becomes infected by inhaling the virus, which enters the respiratory tract and multiplies there and in the spleen, bone marrow and lymph nodes. The liver, spleen and lymph nodes can become enlarged.^19,49

Coming into direct contact with the secretions from open smallpox skin lesions can also spread the disease. Secretions from smallpox lesions can contaminate clothing, bedding, or other materials, which have been used by an infected person, so disinfection of articles used by an infected person is necessary. Hot water containing hypochlorite bleach and quaternary ammonia has been used to decontaminate clothing, bedding and cleaning surfaces possibly exposed to the virus and formaldehyde has been used to fumigate contaminated areas.⁵²

No Contagion for One or Two Weeks: A person with smallpox is infectious from a day before the rash appears (about 10 to 14 days after infection) until all lesions have healed and the scabs have fallen off. In the incubation period of the disease during the two weeks prior to the appearance of a fever and flu-like symptoms, there is no evidence that the smallpox virus sheds and can be transmitted to others and the person looks and feels healthy. Only after the fever and flu-like symptoms begin and then disappear before the outbreak of a rash, will the person be highly contagious and able to infect others through the release of virus in the mouth, throat and respiratory tract. The large amounts of virus shed from the skin lesions can be infectious but are not as infectious as the virus released by the respiratory tract.^49.52

Although persons suffering from variola major, the more severe smallpox, are visibly sick and often bedridden even before the outbreak of the rash, those who have variola minor, the milder smallpox, may not know they are sick until the rash and lesions erupt. Therefore, unsuspecting carriers of a less severe form of smallpox could spread the disease more easily during the early part of the contagious period.

There are estimates that one infected person may transmit the disease to between 5 and 10 other persons in populations with no natural or vaccine-induced immunity.⁵² Those persons can, in turn, infect 5 to 10 others and that is how an epidemic can begin.

Incubation and Symptoms: The incubation period of smallpox from the time of infection to the time that symptoms begin to appear is about 12 to 14 days at which time the person develops a fever of 102 to 106 F., extreme fatigue, severe headache and back pain, and, occasionally, abdominal pain and vomiting. After 3 or 4 days the fever goes down and the patient may appear to recover but then a rash appears on the face and forearms and spreads to the trunk, legs, and, sometimes, appears on the palms and soles of the feet.^20,22,49,52

On the third or fourth day after the rash appears, hard lumps (papules) form under the skin. These papules swell and turn into vesicles (sacs under the skin filled with fluid) that eventually turn into pustules (open skin lesions containing clear, then cloudy fluid filled with pus). A fever often accompanies the rash and formation of papules and vesicles. The pustules, which can resemble chicken pox lesions but are much deeper in the skin, also develop and ulcerate in the mucous membranes of the nose, mouth and throat and release large amounts of virus into the mouth and throat. ^20,22,49,52

The deep ulcerative skin lesions eventually form crusts and scabs that usually fall off within three weeks after the beginning of the illness. The patient can be left with small scars or deep pits in the skin if the sebaceous glands of the skin are destroyed.^20,22,49,52

Rare Types of Smallpox: A milder illness may occur both in those who have been vaccinated and those who have not been vaccinated, including cases that include a rash but no eruption of any lesions (variola sine eruptione). But in another rare form of smallpox, known as malignant smallpox, the disease remains in the rash stage and pustular lesions do not erupt. Malignant smallpox is almost always fatal, as is another rare form of smallpox, known as hemorrhagic smallpox. A person with hemorrhagic smallpox develops fever, bone marrow depression, a drop in platelets (thrombocytopenia) and uncontrollable bleeding into the skin and mucous membranes leading to death.^22,49

Complications and Mortality: The smallpox lesions can become infected, leading to bacterial superinfections usually caused by staphylococcus aureus. Other complications include conjunctivitis (inflammation of the membrane covering the eyeball); bacterial pneumonia; viral arthritis; sepsis (blood infection); encephalomyelitis (inflammation of the brain) and osteomyelitis (inflammation of the bone). Permanent damage can include blindness, brain damage, and severe facial and body scarring. In the past, smallpox killed between one percent and 30 percent of those infected, depending upon whether the person had variola minor or variola major, and mortality was highest in infants and the elderly.^19,22,46,49

Misdiagnosis Can Occur: Before smallpox was eradicated in 1977, doctors sometimes confused chicken pox with smallpox. During the first two to three days of the rash, it is almost impossible to distinguish between the two diseases. The main symptomatic difference between the two is that smallpox lesions are all in the same stage of development while chickenpox lesions can be in various stages of development on different parts of the body. Also, the smallpox rash primarily affects the face and limbs of the body and the chickenpox rash is primarily on the trunk of the body and almost never affects the palms of the hand or soles of the feet like smallpox. Lab tests can distinguish between a herpes group infection (chicken pox) and a poxvirus infection (smallpox).^19,22,52

Other diseases that can mimic smallpox are eczema vaccinatum, eczema herpeticum, rickettsialpox, drug reactions, contact dermatitis, and erythema multiforme (inflammation of the skin and mucous membranes). Meningococcemia, typhus and hemorrhagic fevers can also be mistaken for the more severe fulminant, hemorrhagic smallpox.²²

Human monkeypox, which occurs in Africa, is difficult to distinguish from smallpox. Also, sometimes disseminated vaccinia virus infection (from the vaccine) can be confused with smallpox.¹⁹

Definitive Lab Diagnosis: Lab detection of smallpox can occur within a few hours but definitive identification requires growth of the virus in cell culture or on the chorioallantoic egg membrane and characterization of strains by use of biologic assays, such as polymerase chain reaction (PCR) techniques.^22,49

Treatment for Smallpox Limited: Vaccinia virus vaccine given up to four days after exposure to the virus reportedly can provide protection or lessen the severity of smallpox.⁴⁹ Antibiotics will not cure smallpox because it is a viral, not a bacterial, infection. There are a number of anti-viral medications being investigated, such as cidofovir, but there is no drug currently on the market licensed as a specific treatment for smallpox.⁵²

Like with chicken pox, preventing bacterial infection of the skin lesions is important. Sterile sheets, clothing and other sterile procedures can help reduce complicating bacterial skin infections. Antibiotics to treat secondary infections are given by injection or orally as topical antibiotics are not used. Antihistamines may reduce itching and scratching of the lesions and help prevent their spread to other parts of the body, such as the eyes.^22,52

Early History of Smallpox Prevention: The idea of deliberately exposing a healthy person to biological matter from smallpox lesions of an infected person in order to confer immunity dates back to China several centuries B.C., when Chinese doctors dried and ground up the crusts of smallpox scabs and used tubes to blow the material into the noses of healthy persons. In Africa, Asia Minor and parts of Europe, people swallowed smallpox scabs or had doctors scratch smallpox lymph into their skin (variolation).⁴⁶

In 17^th and 18^th century England and America, it was common practice to scrape smallpox pus from lesions of a person infected with smallpox and then scrape it onto the skin of healthy children and adults in the hope of causing a mild, rather than a severe, form of smallpox. This process became known as variolation. Although smallpox variolation worked for some, it left one in 300 dead and others with severe enough smallpox that they were permanently scarred or blinded from the intervention. Many others were unknowingly infected with syphilis, tuberculosis and hepatitis because the biological matter from smallpox lesions was taken from persons also suffering from those serious diseases. Variolation also contributed to the spread of smallpox throughout populations.⁴⁶

Jenner Uses Cowpox Virus: In 1796, British physician Edward Jenner observed that milkmaids who contracted the generally mild cowpox never came down with the more severe smallpox. (Cowpox is a disease of the teats and udders of cows and when cowpox infects humans it causes low-grade fever, lymph node swelling, and superficial lesions that are much milder than smallpox and heal without scarring. Sometimes cowpox can cause encephalitis and, in persons with a history of eczema, there is a risk of serious infection).²²

Jenner experimented on an eight year old boy. He infected him with cowpox by scraping pus from lesions of a child infected with cowpox onto the skin of the boy. Later, Jenner twice challenged the boy’s immunity to smallpox by scraping pus from the lesions of a person with smallpox onto the boy’s skin. The boy never came down with smallpox and Jenner widely promoted his discovery and advocated cowpox inoculation as a prevention for smallpox.⁴⁶

Vaccinia Virus Emerges: Eventually, Jenner’s method for preventing smallpox was modified and standardized for mass production by the pharmaceutical industry. Apparently, as Jenner refined the cowpox inoculation process, a new virus called vaccinia evolved. To this day, it is unknown exactly how the vaccinia virus came into being but theories are that it is a weakened form of the smallpox or cowpox virus or, more likely, a hybrid of the two viruses.^19,47,53,54 Jenner’s smallpox prevention method became known as “vaccination” and was endorsed by government health officials in Europe and America in the 19th and 20th centuries.

Vaccinia Virus Vaccine Never Tested: The currently licensed vaccine for smallpox contains live vaccinia virus, a double stranded virus with a broad host range. According to Harrison’s Principles of Internal Medicine (1994), “Vaccinia virus never underwent controlled trials to establish safety and efficacy before licensing. Nevertheless, the vaccine was highly effective, despite considerable adverse effects.”¹⁹

There are now multiple strains of vaccinia virus with varying degrees of virulence for humans and animals. Scientists working on new vaccines for diseases, such as HIV, have created recombinant vaccinia viruses from several strains of vaccinia virus.^19,20,53

Wyeth Vaccine From 1970’s Used Calves: When vaccinia virus was used to make smallpox vaccine in the past, it was prepared from the vesicle fluid taken from live calves deliberately infected with vaccinia virus. After the calves were slaughtered, the pustules were scraped to recover fluid and the scrapings were freeze dried. This is how the approximately 15.4 million doses of smallpox vaccine currently stockpiled in the US was manufactured by Wyeth Laboratories in the 1970’s.^21,47

Wyeth used calf vesicle fluid containing a seed virus derived from a New York City Board of Health strain of vaccinia virus.²⁰ This stockpiled vaccine, known as Dryvax, contains trace amounts of polymyxcin B sulfate, streptomycin sulfate, chlortetracycline hydrochloride and neomycin sulfate, as well as glycerin (50%) and phenol (.25%).⁵⁵ Phenol is an extremely poisonous compound obtained by distillation of coal tar and used as an antimicrobial. Ingestion or absorption of phenol through the skin can cause colic, weakness, collapse and local irritation and corrosion.⁵⁶

Stockpiles Have Deteriorated: Reportedly, Dryvax stockpiles have been stored in glass tubes in the form of freeze dried crystals that would be mixed with a liquid diluent just before vaccination using a bifurcated needle that allows droplets of the vaccine to be scratched onto the skin. In 1999 the CDC discovered that some of the U.S. Dryvax smallpox vaccine stockpiles had badly deteriorated: rubber stoppers on the glass storage tubes had decayed and vacuum pressure had been lost while the liquid diluent had changed color and there were only one million bifurcated needles to administer more than 15 million doses.⁵⁷

Old Vaccine Now Being Tested in Volunteers: However, in response to the fear generated after September 11 that smallpox virus stored in the Soviet Union may have fallen into the hands of terrorists in other countries, some of these old stocks of vaccinia virus vaccine are being diluted to one in ten or one in five and given to volunteers at the University of Maryland, St. Louis University, University of Rochester School of Medicine and Baylor College of Medicine to test its effectiveness.^14,15,58 The goal is to increase the numbers of doses of old vaccinia virus vaccine currently available in order to buy time for new vaccine production.

New Vaccines To Use Different Cell Tissues: According to the Working Group on Civilian Biodefense, “The traditional method for producing vaccines on the scarified flank of a calf is no longer acceptable because the product inevitably contains some microbial contaminants, however stringent the purification measures.”⁴⁹ New vaccinia virus vaccines reportedly will not use vaccinia virus cultured from calf vesicle fluid but will be grown in laboratories using other cell tissues such as human fibroblasts (from fetal connective tissue cells).²¹

In the June 22, 2001 MMWR, the CDC confirms that previous methods of vaccine production using calves are no longer being used and that vaccinia virus for new production of smallpox vaccine must be grown using a Food and Drug Administration approved cell culture substrate. The CDC indicates that new cell-culture vaccinia virus vaccine will be evaluated for safety and efficacy by direct comparison with Dryvax using appropriate animal models, serologic and cell-mediated immunity methods and cutaneous indicators of successful vaccination.²⁰

Antibody Level for Protection Unknown: Live vaccinia virus vaccine produces neutralizing antibodies that are genus specific and cross-protective for orthopoxviruses (monkeypox, cowpox, variola). According to the CDC, the efficacy of vaccinia vaccine to prevent smallpox has never been measured precisely during controlled trials and the level of antibody required for protection against smallpox infection is unknown. The level of antibody required for protection against vaccinia virus infection is also unknown. However, more than 95 percent of first-time vaccinees are reported to experience neutralizing or hemagglutination inhibition antibody.²⁰

Duration of Immunity Estimates Vary: According to the CDC, the live vaccinia virus vaccine is protective for five to 10 years.²⁰ The CDC recommends that lab and medical personnel at high risk of being exposed to vaccinia viruses be revaccinated every 10 years.²⁴ However, analysis of a 1902-1903 smallpox outbreak in Liverpool, England as well as a study conducted at the University of Massachusetts Medical Center and published in a 1996 article in the Journal of Virology suggests that varying degrees of immunity from vaccinia virus vaccination may persist for up to 50 years.^59,60 If true, then the oldest half of the US population, which was vaccinated before 1970, may have some remaining immunity to the smallpox virus.

Vaccinia Virus Vaccination Procedure: The method of vaccinia virus vaccination is to withdraw reconstituted vaccine from the vial with a sterile bifurcated (forked) needle, then release a droplet of vaccine onto the skin over the deltoid muscle in the upper arm; then repeatedly press (15 times) the forked needle into the superficial layer of skin covered with vaccine hard enough to draw traces of blood. A loose, porous bandage or gauze held with tape is then applied to help prevent the person from touching the vaccination site and transferring the live virus to other parts of the body or to other persons.^20,52

Two to five days after inoculation, a red papule (lump) at the site should appear. On day five or six, the papule should swell and fill with fluid (turn into a vesicle). Between days seven and 11, the vesicle should turn into a pustule (become an open, pus-filled lesion). About two weeks after vaccination, the pustule dries and develops a crust that falls off by the end of the third week and leaves the characteristic smallpox scar on the skin.²²

If a person is already partially immune to smallpox (either through previous experience with the disease or vaccination), there may be an accelerated process that includes a papule that appears within 3 days, vesiculates in 5 to 7 days, and heals with little scarring. If only a papule develops without vesiculation and without leaving some kind of scar, it is considered a failed vaccination and many times the person is revaccinated in an attempt to get a “Jennerian vesicle” that is considered proof of successful vaccination.²²

The live vaccinia virus vaccine to prevent smallpox may be the most highly reactive vaccine that has ever been used in humans. As with most vaccines, when complications occurred with the vaccinia virus vaccine, they were quite similar to the complications of the disease they were designed to prevent.

According to the World Health Organization “existing vaccines have proven efficacy but also have a high incidence of adverse side-effects. The risk of adverse events is sufficiently high that vaccination is not warranted if there is no or little real risk of exposure. Vaccine administration is warranted in individuals exposed to the virus or facing a real risk of exposure. A safer vaccinia-based vaccine, produced in cell culture is expected to become available shortly. There is also interest in developing monoclonal antivariola antibody for passive immunization of exposed and infected individuals, which could also be safely administered to persons infected with HIV.”⁵²

Potential 70,000 Severe Reactions Requiring VIG: According to the Working Group on Civilian Biodefense “It has been estimated that if 1 million persons were vaccinated [with live vaccinia virus vaccine], as many as 250 persons would experience adverse reactions of a type that would require administration of VIG [vaccinia immune globulin].”⁴⁹

Using these vaccine risk estimates would yield a serious vaccine reaction rate of 1 in 4,000 persons. This would mean that out of 280 million Americans who receive the vaccinia virus vaccine there could be approximately 70,000 persons who would experience reactions severe enough to require VIG.

VIG is ineffective in treating postvaccinal encephalitis.²⁰ Estimates are that postvaccinal encephalitis following live vaccinia vaccine occurs in between 1 in 81,000 to 1 in 345,000 persons receiving their first smallpox vaccination,^20,22 which would add thousands of cases of postvaccinal encephalitis in the initial mass vaccination of all Americans, for whom VIG treatment is not beneficial.

Potential Neurological Reactions in the Young: One 1992 study by the State Research Institute of Standardization and Control of Medical Biologics in Russia reported a neurological complication rate of 1 in 3,200 persons aged five years and older who received a first live vaccinia virus vaccination.⁶¹ Approximately 120 million Americans are between the ages of 5 and 35 according to the US 2000 census. If all those Americans were first-time vaccinees, approximately 37,500 of them could suffer a neurological reaction.

Re-Introducing Vaccinia Virus A Risk: The vaccinia virus vaccine has not been used on a mass basis in the U.S. since the early 1970’s so the virus is not circulating in our population and no one under age 30 has had any experience with it. Because live vaccinia virus vaccine can cause vaccinia viral infection in the vaccine recipient or in a close contact of the recently vaccinated person, those who get vaccinated will be exposing themselves and others to the vaccinia virus and potential complications.

The CDC reports that one 10-state survey revealed that transmission of vaccinia virus infection occurred in 27 per million total vaccinations (1 in 37,000 vaccinations) and 44 percent of those contact cases occurred among children. Approximately 60 percent of contact transmissions in the survey resulted in the inadvertent inoculation of otherwise healthy persons. About 30 percent of the eczema vaccinatum cases were a result of contact transmission.^20,62

Common Vaccinia Virus Vaccine Reactions: Fever, fatigue and irritability are common, especially in children, during the vesicular and pustular stages and swollen lymph glands may persist for months after vaccinia virus vaccination.²²

Inadvertent inoculation at other body sites: According to the CDC: “Inadvertent inoculation at other sites is the most frequent complication of vaccinia vaccination and accounts for approximately half of all complications of primary vaccination and revaccination.” Autoinoculation occurs when the recently vaccinated person touches or scratches the lesion at the vaccination site and transfers the live vaccinia virus to other parts of the body, such as the face, eyelid, nose, mouth, genitalia and rectum, and more lesions form. Most lesions heal without therapy but vaccinia immunoglobulin (VIG) can be used when the eye is involved, unless there is inflammation of the cornea (because VIG can increase corneal scarring). The CDC estimates inadvertent inoculation occurs in 1 in 1,890 first time vaccinations.²⁰

Fever: According to the CDC, approximately 70 percent of children experience temperatures under 100 F. for 4-14 days after the first vaccination and 15-20 percent will experience temperatures under 102 F. After revaccination, 35 percent of children experience temperatures under 100 F. and 5 percent experience temperatures under 102 F. Fever is less common in adults. ²⁰

Rashes and Hives: A raised rash (erythema) or hives (urticaria) can occur approximately 10 days after a first vaccination, which usually does not involve a fever and resolves within two to four days. Sometimes erythema and urticaria can be confused with generalized vaccinia. ²⁰

More Severe Reactions: Moderate and severe immune and neurological complications of live vaccinia vaccination occur more than ten times more often among first-time vaccinees than among those who are revaccinated and are more frequent among infants. ²⁰ Well known serious complications of live vaccinia virus vaccination include progressive vaccinia, postvaccinal encephalomyelitis; eczema vaccinatum; and generalized vaccinia, and reaction rates for these serious vaccine complications vary.

Progressive Vaccinia (vaccinia gangrenosa, vaccinia necrosum): When the live vaccinia virus continues to grow in the body and healing of the primary vaccinal lesion caused by smallpox vaccination does not occur, there can be a slowly progressive destruction of large areas of skin (necrosis), subcutaneous tissue, viscera (internal organs) and bone. Progressive vaccinia almost always occurs in persons with a severe immune deficiency caused by cancer, radiation or chemotherapy, and AIDS or other serious immune system disorders such as lupus. Those who develop progressive vaccinia almost always die within six months.^19,20,22,49

In the past, it was estimated that this reaction occurred in 1 in 1 million to 1.6 in 1 million vaccinations with a case fatality ratio of almost 90 percent.^20,22,53 However, this severe reaction to live vaccinia virus vaccine will most likely occur more often today if mass smallpox vaccination campaigns are introduced in populations with a high incidence of undiagnosed HIV/AIDS or other immune system deficiencies.

Postvaccinal Encephalitis/Encephalomyelitis: Inflammation of the brain can develop two to 25 days after vaccination.²² It occurs most frequently in children under age one or two years and in older children and adults receiving their first smallpox vaccination.^20,53,61 Symptoms can appear suddenly and include fever, vomiting, drowsiness, restlessness, confusion, convulsions, hemiplegia (partial paralysis), aphasia (loss of speech), loss of consciousness and coma. Recovery is often incomplete, with residual brain damage and paralysis, which occurs most frequently in children under two years old.⁵³ Death rates following post vaccinal encephalitis range from 25 percent to 50 percent of patients, usually within a week of onset.^20,53 Conservative estimates of frequency range from 1 in 345,00022 to 1 in 81,000 persons receiving their first-vaccination.²⁰

Eczema Vaccinatum: This reaction is seen in persons with a history of eczema or other types of chronic skin conditions like contact dermatitis. The person develops high fever, swollen lymph nodes and widespread inflammation and appearance of lesions on areas of skin previously affected by eczema that can spread to areas of healthy skin. Especially severe cases can occur when persons, who have active eczema or a history of eczema, come in contact with those recently vaccinated with live vaccinia virus.^20,22 The CDC states “Eczema vaccinatum might be more severe among contacts than among vaccinated persons.”²⁰ Eczema vaccinatum can be mild and self limited but also can be severe and fatal. Estimates of frequency ranges from 1 in 100,000¹⁹ to 1 in about 26,000 first time vaccinations.²⁰

Generalized Vaccinia: This reaction involves a vesicular rash similar to but milder than smallpox that can be localized around the vaccination site or cover the body and can occur among healthy persons without underlying illness. It is most serious in those who have underlying immunosuppressive illness. The CDC estimates that 241.5 cases of generalized vaccinia per 1 million first time vaccinations occurs (about 1 in 4,100 vaccinations).²⁰

Death: Death from vaccinia vaccination is most often the result of postvaccinal encephalitis or progressive vaccinia. Death has been estimated to occur in 1 in 1 million vaccinated persons.²²

Other Serious Vaccinia Vaccine Reaction Reports: There are a number of other serious vaccinia vaccine reactions reported in the medical literature, including progressive or generalized vaccinia in persons with genital herpes,^63,64,65 HIV,⁶⁶ and active acne;⁶⁷ development of skin cancer;⁶⁸ basal cell carcinoma in a smallpox vaccination scar;⁶⁹ discoid lupus erythematosus in a smallpox vaccination scar;⁷⁰ diabetes;⁷¹ thrombocytopenia purpura;⁷² cardiac complications leading to heart damage;^73,74 clubfoot in babies whose mother’s were vaccinated in the first trimester;⁷⁵ and chromosomal breakage and changes in children after revaccination.^76,77

VIG Treatment and Prevention of Vaccine Complications: Treatment for and prevention of vaccinia complications is limited. Vaccine Immune Globulin (VIG), which is composed of preformed antibody to vaccinia virus taken from the blood of persons who have already been vaccinated with vaccinia virus, has been used in cases of autoinoculation of the eye, progressive vaccinia, eczema vaccinatum and generalized vaccinia. VIG is of no use in cases of postvaccinal encephalitis.²⁰

VIG has also been used to try to prevent serious vaccine reactions by giving persons with contraindications (such as immune suppression) VIG before vaccination.^20,49. Although VIG has been useful in treating some cases of vaccinia vaccine reactions, there is no assurance that VIG will either prevent or modify the course of every serious reaction.

The stockpiled supply of old VIG reportedly has deteriorated over the years and is limited.^26,57 There is not enough VIG to treat the number of serious vaccine reactions that are estimated would occur if all of the 15.4 million doses of stockpiled Dryvax vaccine were used.^14,20,26,49 The blood from volunteers in current Dryvax trials using diluted old vaccine may be able to be utilized to make more VIG.^14,15,58

Contraindications: According to Harrison’s Principles of Internal Medicine, contraindications to vaccinia virus vaccine include: B or T cell immune system disorders, eczema, pregnancy, disorders of the central nervous system, neoplasms of the reticuloendothelial system, and use of immunosuppressive drugs.¹⁹

The CDC now lists the following contraindications in the absence of an emergency (actual exposure to smallpox):²⁰

· Persons who experience anaphylactic reactions to polymyxin B sulfate, streptomycin sulfate, chlortetracycline hydrochloride and neomycin sulfate should not be vaccinated with Dryvax;

· Persons with eczema or other skin conditions: “Vaccinia vaccine should not be administered to persons with eczema of any degree, those with a past history of eczema, those whose household contacts have active eczema, or whose household contacts have a history of eczema. Persons with other acute, chronic or exfoliative skin conditions (e.g., atopic dermatitis, burns, impetigo or varicella zoster) might also be at higher risk for eczema vaccinatum and should not be vaccinated until the condition resolves.”

· Persons with immunosuppression (leukemia, lymphoma, generalized malignancy, solid organ transplantation, cellular or humoral immunity disorders, therapy with akylating agents, antimetabolites, radiation or high-dose corticosteroid therapy);

· Pregnant Women: “Vaccinia virus has been reported to cause fetal infection on rare occasions, almost always after primary vaccination of the mother. Cases have been reported as recently as 1978. When fetal vaccinia does occur, it usually results in stillbirth or death of the infant soon after delivery.”

Other contraindication considerations : Although the CDC does not list herpes infection as a contraindication in non-emergencies, the case reports of progressive vaccinia in persons with herpes suggest that use of the vaccinia virus vaccine today may result in many more cases of progressive vaccinia than in the past. Herpes infection, like HIV, is more widespread today than it was prior to the early 1970’s, when routine vaccinia virus vaccination was discontinued.

“No absolute contraindications exist regarding vaccination of a person with a high-risk exposure to smallpox. Persons at greatest risk for experiencing serious vaccination complications are also at greatest risk for death from smallpox. If a relative contraindication to vaccination exists, the risk for experiencing serious vaccination complications must be weighed against the risk for experiencing a potentially fatal smallpox infection. When the level of exposure risk is undetermined, the decision to vaccinate should be made after prudent assessment by the clinician and the patient of the potential risks versus the benefits of smallpox [vaccinia virus] vaccination.”

Other Considerations: Whether a person dies from a disease or a vaccine, a death is a death and one cause of death is no more important than another when individual human life is valued. Because there are no genetic or other biomarkers to definitively predict ahead of time who will be harmed by vaccination, there must be strict adherence to the informed consent ethic, especially during times of emergencies when all contraindications are officially suspended. To do any less, places public health officials and anyone, who forces vaccination on a person without that person’s informed consent, in the role of judge and executioner of the genetically and biologically vulnerable.

Preventing Contact Transmission of Vaccinia Virus: Care must be taken to prevent spread of the vaccine virus from the vaccination lesion site to other areas of the body or to another person. Use of gauze or porous bandages (to allow air to dry the site lesion) is advised with bandages changed every 1 to 2 days. No salves or ointments should be placed on the vaccination lesion. The most important action for preventing vaccinia virus transmission is frequent hand washing with soap and water or disinfecting agents after contact with the vaccination site. Disposal of bandages that have covered the site in sealed plastic bags and decontaminating clothing or materials that have contact with the site by laundering in hot water with bleach is also important.^20,52

Recombinant Vaccinia Virus Vaccine Transmission: Scientists are using vaccinia virus as a vehicle for creating new vaccines. Genes from herpes simplex virus, hepatitis B virus, HIV and malaria reportedly have been inserted into the vaccinia genome.¹⁹ In the 1970’s and 1980’s, as researchers began experimenting with genetically engineering different strains of vaccinia viruses to contain and express foreign DNA to induce protection against infectious agents such as HIV, there were reports of laboratory-acquired infections with vaccinia or recombinant viruses.^20,24

In 1991 the CDC’s Advisory Committee on Immunization Practices (ACIP) advised that health care workers, who were exposed to volunteers in new vaccine trials using genetically engineered vaccinia virus, be vaccinated with vaccinia virus vaccine. The CDC recommendations stated that::

“With the initiation of human trials of recombinant vaccines, physicians, nurses and other health-care personnel who provide clinical care to recipients of these vaccines could be exposed to both vaccinia and recombinant viruses. The exposure could occur from contact with dressings contaminated with the virus or through exposure to the vaccine. The risk of transmission of recombinant viruses to exposed health care workers is unknown…however, because of the potential for transmission of vaccinia or recombinant vaccinia viruses to such persons, the ACIP suggests that health care personnel who have direct contact with contaminated dressings or other infectious material from volunteers in clinical studies be considered for vaccination.”²⁴

Health Secretary Orders 300 Million Doses of Vaccine: One month after the September 11 terrorist attacks on the World Trade Center and the Pentagon, DHHS Secretary Tommy Thompson called on industry and government to produce and stockpile 300 million doses of vaccinia virus vaccine by the end of 2002. He said that all Americans should know they “have their name on a vaccine shot in our inventory.” Cost estimates range from $500 million to nearly $2 billion.^1,15,78 In order to be able to accomplish this goal, some in industry are calling for cutting the number of participants in vaccine trials and bypassing standard safety and efficacy requirements to quickly create a stockpile of vaccine.^16,17,25

Industry Asks for Immunity From Lawsuits: Drug companies competing for the multi-million dollar contract to produce enough vaccinia virus vaccine to vaccinate every American are asking Congress to pass legislation shifting all liability for vaccine injuries and deaths to the government (American taxpayer). Already, there are bills being drafted in Congress to create a federal fund to compensate victims of bioterrorism vaccines, such as vaccinia virus vaccine.⁷⁹

New Office of Preparedness Created: DHHS Secretary Thompson has appointed D.A. Henderson, founding director of the Center for Civilian Biodefense Studies at Johns Hopkins University and architect of the worldwide smallpox eradication effort, as well as Philip Russell, a retired Army major general specializing in vaccine development, to head a new Office of Preparedness that will expand new vaccine programs and develop strategies to respond to public health emergencies. Dr. Henderson has been quoted as saying his top priority is to improve the “communications system” that will allow the medical community and government to mount a coordinated response.⁸⁰

Emergency Plan Will Militarize Public Health System: The Working Group on Civilian Biodefense has stated “The discovery of a single suspected case of smallpox must be treated as an international health emergency.”⁴⁹ Although it is very important to have a well crafted bioterrorism emergency response plan in place, along with enough vaccine for everyone who wants to use it, it is difficult to envision the necessity for giving public health officials the kind of sweeping police powers now being advocated by the Centers for Disease Control (CDC).

With funding and direction provided from the CDC, a lawyer at the Georgetown University Center for Law and the Public’s Health, Lawrence Gostin, has created model state legislation that will allow public health officials to mobilize and use “all or any part of the organized militia” to isolate, quarantine and force vaccination and medical treatment on American citizens in states where a Governor has called a “state of emergency” for 30 days or more. (Go to www.publichealthlaw.net to read the law).

Public health officials would be given the power to “coordinate all matters pertaining to the public health emergency,” including the right to seize private property such as “communications devices, carriers, real estate, fuels, food, clothing and health care facilities” and take control of “the use, sale, dispensing, distribution and transportation of food, fuel, clothing and other commodities, alcoholic beverages, firearms, explosives and combustibles” as well as take control of roads and public areas.

If passed by the states, the law would give unprecedented police powers to public health officials and those they designate to charge citizens with misdemeanors and imprison them if they refuse to comply with vaccination, medical treatment or isolation orders without being able to go to court first. Those who participate in enforcing the law would not be held liable for any injury, death or loss of property which resulted.

In the preface to this model state legislation, Gostin justified the law he wrote for the CDC by referring to the 1905 Supreme Court decision Jacobsen v Massachusetts, which upheld the right of US states to pass mandatory vaccination laws. Gostin, who is a longtime forced vaccination proponent, will be working with the National Governors Association, National Conference of State Legislatures, Association of State and Territorial Health Officials, National Association of City and County Health Officers, and National Association of Attorneys General to get this legislation passed in every state. It has already been introduced in Massachusetts.

Jacobsen v Massachusetts Revisited: How did we get to this point in America, where public health officials would presume to appropriate the kind of police power they are now saying they should be given? It all goes back to a man name Jacobsen who, in 1905, sued the state of Massachusetts for requiring him and his son to get a second vaccinia virus (smallpox) vaccination or pay a $5 fine. Jacobsen refused to get revaccinated or pay the fine, saying that he and his son had had a bad reaction to a previous vaccination for smallpox and were afraid they would be injured or die from a second one. Jacobsen maintained that forcing him to be revaccinated was “an assault upon his person” and violated his constitutional rights.

In its majority opinion in Jacobsen v Massachusetts, 197 U.S. 11(1905), the Supreme Court rejected the evidence Jacobsen presented to show that the vaccine can cause injury and death and that doctors cannot distinguish between those who will be harmed and those who will not be harmed. The Court concluded, “The matured opinions of medical men everywhere, and the experience of mankind, as all must know, negative the suggestion that it is not possible in any case to determine whether vaccination is safe.”

Doctors Cannot Predict Who Will Be Harmed: The fact the Supreme Court at the turn of the 20th century did not have accurate medical information upon which to base their precedent-setting decision is unfortunate. It has been proven in the succeeding 96 years, most recently in the US Court of Claims in Washington, D.C. where nearly two billion dollars has been awarded to families whose children have been killed or been injured by mandated childhood vaccines, that often doctors cannot predict ahead of time which individuals will react to vaccines and die or be left with mental retardation, medication-resistant seizure disorders, paralysis, learning disabilities, ADHD, autism, chronic arthritis, or other immune and brain dysfunction.⁶

Cruel and Inhuman To The Last Degree: This is a critical point in measuring the consequences of assigning police powers to public health officials for the purpose of enforcing vaccination, particularly in cases where parents suspect their children are at increased risk for reacting to vaccines - even though government health officials, anxious to achieve a 100 percent vaccination rate, disagree. In their opinion, the 1905 Supreme Court justices acknowledged that vaccination must not be forced on a person whose physical condition would make vaccination “cruel and inhuman to the last degree. We are not to be understood as holding that the statute was intended to be applied in such a case or, if it was so intended, that the judiciary would not be competent to interfere and protect the health and life of the individual concerned.”

Therefore, when interpreting Jacobsen v Massachusetts in 2002, it is important to remember that, although the Court agreed that states may enact “such reasonable regulations established directly by legislative enactment as will protect the public health and the public safety,” the Supreme Court made it clear that mandatory vaccination laws must not be applied unreasonably so as to result in harm to individuals. In other words, the state does not have the right to command that an individual sacrifice his or her life in the name of the public health.

Utilitarianism Was in Fashion: What, then, did the 1905 Supreme Court mean when it went on to declare that “it was the duty of the constituted authorities primarily to keep in view the welfare, comfort and safety of the many, and not permit the interests of the many to be subordinated to the wishes or convenience of the few?” The “wishes or convenience” of the few certainly does not translate into the ”lives” of the few, but still, the historical context in which this declaration was made is very important.

In 1905, the political doctrine known as “utilitarianism” was a popular philosophical tenet, which judged the rightness or wrongness of an action by its consequences and held that an action that is moral or ethical results in the greatest happiness for the greatest numbers of people. With its emphasis on numbers of people, utilitarianism became a convenient way to justify state legislative policy. Karl Marx used utilitarian principles to formulate his economic theories and modern cost benefit analyses are also descendents of utilitarianism.¹²

Individual Autonomy Must Come First: In 1927, jurist Oliver Wendall Holmes embraced the utilitarian rationale when he used Jacobsen v Massachusetts to justify the forced sterilization of a mentally retarded woman to, in effect, protect the public welfare. Writing for the majority in a 8-1 Supreme Court decision, Buck v Bell, 274 U.S. 200 (1927), Holmes said “The principle that sustains compulsory vaccination is broad enough to cover cutting the Fallopian tubes.”

Not long after, Hitler would embrace the same kind of rationalization used by Holmes in that stunning 1927 legal opinion and go on to pursue his own brand of social engineering to eliminate from society those persons the Third Reich had judged to be genetically inferior, physically or mentally compromised, or socially unacceptable (homosexuals, political dissidents) because they were thought to be a threat to the public health and welfare.⁸¹ The tragic moral failure of utilitarianism was finally revealed at the Doctor’s Trial at Nuremberg after World War II, where it was discredited by the Nuremberg Tribunal as a pseudo-ethic.¹¹ In its place stands the Nuremberg Code, which places the right of individuals to self determination and autonomy above the right of the state, science and medicine to derive benefits from them.

The human right to informed consent to medical interventions that can injure or kill is the centerpiece of modern bioethics. It insures that the individual has control over decisions and actions involving life and death, which are the most sacred of all decisions and actions humans are ever called upon to make.

Like every American, I never imagined that I would experience the kind of shock and horror that came on September 11 with the terrorist attacks on New York and Washington, D.C. While our world has changed forever, there are some things that never change. Truth does not change. What it means to be free does not change.

In response to the fear and anxiety that still hangs like a bad dream over our nation, in the mad scramble to “do something” to make Americans feel safe again, government officials employed by the Centers for Disease Control (CDC) have stepped forward to suggest that they and their state health department counterparts are the only ones who can keep us safe whenever they decide there is a “public health” emergency – if only we will give them the power to use the state militia to arrest, quarantine and forcibly vaccinate and medicate us. Not satisfied with that, they also want the power to seize our private property, including our homes, as well as our telephones, fax machines, computers, cars, fuel, food, clothing, firearms, prescription drugs and the alcoholic beverages in our refrigerator. Just in case you were thinking you could make it to the border before the public health militia comes to get you, they want the power to take over all roads in and out of your city and state, too.

And to make sure they can’t get sued by anyone for anything they do, they are asking for total legal immunity for destroying your property or killing you or your children when they enforce the law. They are joined in this quest by the drug companies making “bioterrorism” vaccines, like the notoriously reactive smallpox vaccine never tested for safety in clinical trials. Not only are the drug companies demanding that Congress give them total legal immunity for all vaccine-induced injuries and deaths, they are also demanding that the bioterrorism vaccines they produce be exempt from normal federal safety and efficacy standards.

Certainly, America should have enough smallpox vaccine or other “bioterrorism” vaccines for everyone who voluntarily wants to use them: but not ones that haven’t been properly tested. Certainly, America should have a sound, workable emergency plan in place in the event of a bioterrorism attack: but not one that places the life and liberty of the majority of citizens in the hands of an elite few, who will have the power to take both from citizens without their consent.

This CDC-funded and initiated legislation treats us like runaway slaves in need of subjugation. The law’s proposed elimination of the informed consent principle, which has governed the ethical use of medical interventions that can injure or kill ever since the Doctor’s Trial at Nuremberg after World War II, is clear indication that public health officials want the sole authority to decide who will live and who will die and under what conditions.

No state of emergency in a free society justifies the sacrifice of the most sacred human right: the right to voluntarily decide what you are willing to risk your life for or your child’s life for. What it means to be free doesn’t get more basic than that.

I have said many times during the past decade, that if the state can tag, track down and force citizens to be injected with biologicals of unknown toxicity today, then there will be no limit on what individual freedoms the state can take away in the name of the greater good tomorrow. Now, tomorrow is here.

REFERENCES:

1. Miller J, Stolberg SG. October 22, 2001. Sept. 11 Attacks led to push for more smallpox vaccine. The New York Times.

2. Hudson A. October 10, 2001. Anthrax, smallpox vaccines called for. The Washington Times.

3. Gostin Lawrence, J.D., Georgetown University, for the CDC: The Model State Emergency Health Powers Act (www.publichealthlaw.net).

4. Gillis J. November 19, 2001. States weighing laws to fight bioterrorism. The Washington Post.

5. Coulter HL, Fisher BL. 1985. DPT: A Shot in the Dark. San Diego: Harcourt Brace Jovanovich.

6. National Childhood Vaccine Injury Act of 1986 (Public Law 99-660; 42 USC 300aal et seq.)

7. Institute of Medicine. 1991. Adverse Effects of Pertussis and Rubella Vaccines. Washington, D.C: National Academy Press.

8. Institute of Medicine. 1994. Adverse Effects Associated with Childhood Vaccines: Evidence Bearing on Causality. Washington, D.C: National Academy Press.

9. Institute of Medicine. 1994. DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis. Washington, D.C: National Academy Press.

10. Centers for Disease Contro1. 1987. Pertussis immunization: family history of convulsions and use of antipyretics – Supplementary ACIP Statement. Morbidity and Mortality Weekly Report

11. Annas GJ, Grodin MA. 1992. The Nazi Doctors and the Nuremberg Code. New York: Oxford University Press.

12. Arras JD, Steinbock B., eds. Ethical Issues in Modern Medicine. Mountain View: Mayfield Publishing Co.

13. Kolata G. October 22, 2001. ‘Cure’ for bioterror may be worse than the disease. The New York Times.

14. Landers SJ. November 12, 2001. Smallpox vaccine: balancing the benefits and the risks. American Medical News.

15. Connolly C. November 7, 2001. HHS set to order smallpox vaccine for all Americans. The Washington Post.

17. Dyer G., Cookson, C. October 11, 2001. Spreading calm in small doses. Financial Times.

19. Isselbacher KJ, Braunwald E et al, eds. 1994. Harrison’s Principles of Internal Medicine. Thirteenth Edition. New York: McGraw-Hill.

20. Centers for Disease Control. June 22, 2001. Vaccinia (Smallpox) Vaccine Recommendations of the Advisory Committee on Immunization Practices (ACIP) 2001. Morbidity and Mortality Weekly Report.

21. Gillis, J, Okie S. October 28, 2001. US mounts smallpox vaccine push. The Washington Post.

22. Braunwald E, Isselbacher KJ et al, eds. 1987. Harrison’s Principles of Internal Medicine. New York: McGraw-Hill.

23. Centers for Disease Control. June 14, 1985. Recommendation of the Immunization Practices Advisory Committee: Smallpox Vaccine. Morbidity and Mortality Weekly Report.

24. Centers for Disease Control. December 13, 1991. Vaccinia (Smallpox) Vaccine Recommendations of the Immunization Practices Advisory Committee (ACIP). Morbidity and Mortality Weekly Report.

25. Gillis J. November 8, 2001. Scientists race for vaccines. The Washington Post.

26. Bradsher K. October 22, 2001. US begins search for medicine used to treat adverse reactions to smallpox vaccine. The New York Times.

27. Disability Statistics Rehabilitation Research and Training Center, University of California, San Francisco. November 1996. Trends in disability rates in the United States, 1970-1994. US Department of Education, National Institute on Disability and Rehabilitation Research Disability Statistics Abstract.

28. Cookson WO, Moffatt MF. January 1997. Asthma: an epidemic in the absence of infection? Science.

29. Centers for Disease Control. 1995. Asthma-United States, 1982-1992. Morbidity and Mortality Weekly Report.

30. Centers for Disease Control. 1995. Disabilities among children aged less than or equal to 17 years – United States 1991-1992. Morbidity and Mortality Weekly Report.

31. US Department of Education, Office of Special Education and Rehabilitative Services. 1997. 20th Annual Report to Congress on the Implementation of the Individuals with Disabilities Education Act.

33. Zito JM, Safer DJ et al. 2000. Trends in prescribing psychotropic medications to preschoolers. Journal of the American Medical Association.

34. Cowart VS. 1998. Attention-deficit hyperactivity disorder: physicians helping parents pay more heed. Journal of the American Medical Association.

35. Centers for Disease Control. 1997. Trends in the prevalence and incidence of self-reported diabetes mellitus – United States 1980-1994. Journal of the American Medical Association.

36. Marwick C. April 7,1999. Diabetes research plan presented to congress. Journal of the American Medical Association.

37. Department of Developmental Services. March1,1999. Changes in the Population of Persons with Autism and Pervasive Developmental Disorders in California’s Developmental Services System: 1987 through 1998: A Report to the Legislature. (www.dds.ca.gov)

38. US Department of Education. 1998. Twentieth Annual Report to Congress on the Implementation of the Individuals with Disabilities Education Act.

39. Centers for Disease Control. January 12, 2001. Recommended Childhood Immunization Schedule – US, 2001. Morbidity and Mortality Weekly Report.

40. American Academy of Pediatrics. 1970. A Report of the Committee on Infectious Diseases: Sixteenth Edition.

44. Porter R. 1997. The Greatest Benefit to Mankind. New York: W.W. Norton & Co.

45. Spencer J, Scardaville M. October 11, 2001. Understanding the bioterrorist threat: facts and figures. The Heritage Foundation Backgrounder (www.heritage.org/library/backgrounder)

47. Brownlee S. October 28, 2001. Clear and present danger. The Washington Post Magazine.

48. Miller J. November 16, 2001. US set to retain smallpox stocks. The New York Times.

49. Henderson DA, Inglesby TV et al. June 9,1999. Smallpox as a biological weapon (Consensus Statements of the Working Group on Civilian Biodefense). Journal of the American Medical Association.

50. U.S. General Accounting Office. September1999. GAO Report: The Department of Health Combating Terrorism: Need for a Comprehensive Threat and Risk Assessments of Chemical and Biological Attack, GAO/NSIAD-99-163.

51. Henderson DA. July-September 1998. Bioterrorism as a public health threat. Emerging Infectious Diseases.

52. World Health Organization. 2001. Smallpox. Weekly Epidemiological Record 76.

53. Kaplan C. 1989. Vaccinia virus: a suitable vehicle for recombinant vaccines? Archives of Virology.

58. Argetsinger A. October 27,2001. Smallpox vaccine studies swamped with volunteers. The Washington Post.

59. Demkowicz WE, Littalia RA et al. 1996. Human cytotoxic T-cell memory: long lived responses to vaccinia virus. Journal of Virology:

60. Cohen J. October 28, 2001. And now, the good news about smallpox. (http://slate.msn.com)

61. Gurvich EB. 1992. The age-dependent risk of post-vaccination on complications in vaccinees with smallpox vaccine. Vaccine.

62. Lane JM, Ruben FL et al. 1970. Complications of smallpox vaccination, 1968: results of ten statewide surveys. Journal of Infectious Diseases.

63. Funk EA, Strausbaugh LJ. March 1981. Vaccinia necrosum after smallpox vaccination for herpes labialis. Southern Medical Journal.

65. Lane JM. May 21,1982. Hazards of smallpox vaccination. Journal of the American Medical Association.

66. Redfield RR, Wright DC et al. March 12,1987. Disseminated vaccinia in a military recruit with human immunodeficiency virus (HIV) disease. New England Journal of Medicine.

67. Centers for Disease Control. December 24, 1982. Epidemiologic Notes and Reports: Disseminated vaccinia infection in a college student – Tennessee. Morbidity and Mortality Weekly Report.

68. Michel N, Aguilera A. March 1976. Vaccinia virus: the possibilities of its oncogenicity in humans. Cancer Letters.

69. Riberio R, Labareda JM. 1988. Basocellular carcinoma in a smallpox vaccination scar. Medicina Cutanea Ibero Latino Americana.

70. Lupton GP. October 1987. Discoid lupus erythematosus occurring in a smallpox vaccination scar. Journal of the American Academy of Dermatology.

71. Schneider H. March 1975. Manifestation of diabetes after smallpox vaccination. Kinderarztliche Praxis.

72. Burke PJ, Shah NR. September 1981. Thrombocytopenic purpura after smallpox vaccination. Pennsylvania Medicine.

73. Moschos A., Papaioannou AC. October 1976. Cardiac complications after vaccination for smallpox. Helvetica Paediatrica Acta.

74. Feery BJ. August 6,1977. Adverse reactions after smallpox vaccination. Medical Journal of Australia.

75. Naderi S. August 1975. Smallpox vaccination during pregnancy. Obstetrics and Gynecology.

76. Knuutila S, Maki-Paakkanen J et al. 1978. An increased frequency of chromosomal changes and SCE’s in cultured blood lymphocytes of 12 subjects vaccinated against smallpox. Human Genetics.

77. Kucerova M, Polivkova Z. 1980. Chromosomal aberrations and SCE in lymphocytes of children revaccinated against smallpox. Mutation Research.

78. Bradsher K. November 7, 2001. Smallpox vaccine costlier than expected. The New York Times.

79. Bradsher K. November 8, 2001. Three smaller companies say their vaccines are cheaper. The New York Times.

80. Connolly C. November 8, 2001. . US officials reorganize strategy on bioterrorism. The Washington Post.

81. Weindling P. 1989. Health, Race and German Politics Between National Unification and Nazism 1870-1945. Cambridge: Cambridge University Press.

For More Information: At this NVIC website, http://www.909shot.com, you can access links to other vaccine and health information resources, as well as sign up to subscribe to NVIC’s free Vaccine E-News Service or become a member of the National Vaccine Information Center.

About the Editor

Barbara Loe Fisher is co-founder and president of the National Vaccine Information Center. She is co-author of DPT: A Shot in the Dark (Harcourt Brace Jovanovich, 1985; Warner, 1986; Avery, 1991), a book which made an important contribution to public support for development of the purified pertussis vaccine licensed by the FDA for American babies in 1996. She is author of The Consumer’s Guide to Childhood Vaccines (NVIC, 1997) and editor of THE VACCINE REACTION and The Vaccine Hotline newsletters.

During the 1980’s, she helped lead a national grassroots effort to bring the issue of vaccine safety to public attention, including leading demonstrations at the Centers for Disease Control in Atlanta and at the White House in 1986. Later that year, Congress passed the National Childhood Vaccine Injury Act.

She served on the National Vaccine Advisory Committee for four years, where she was chair of the subcommittee on adverse events. She was appointed to the Vaccine Safety Forum at the Institute of Medicine in 1995, where she helped to coordinate five public workshops on vaccine safety. She has served as the consumer voting member of the FDA Vaccines and Related Biological Products Advisory Committee since 1999. She is a frequent public speaker at educational health conferences, where she defends the right to informed consent to medical interventions which can cause injury or death, including vaccination.

The mother of three children, in 1980 her two and a half year old son reacted within four hours of his fourth DPT and polio vaccinations with a convulsion, collapse shock and six hour state of unconsciousness. He was left with minimal brain dysfunction, including multiple learning disabilities and attention deficit disorder.

The National Vaccine Information Center (NVIC), founded in 1982 by parents of vaccine injured children, is a non-profit, educational organization (501C3) dedicated to preventing vaccine injuries and deaths through public education. NVIC promotes scientific research into the biological causes of vaccine injury and death in order to identify biomarkers which place individuals at high risk for suffering vaccine reactions. NVIC advocates the institution of informed consent protections in mass vaccination laws and serves as a watchdog on vaccine research, development, regulation and promotion activities of public health agencies.

After launching the vaccine safety and informed consent movement in the U.S. in the early 1980’s, NVIC’s co-founders worked with Congress to create the National Childhood Vaccine Injury Act of 1986. This historic law set up a vaccine injury compensation program and included vaccine safety provisions, such as mandatory reporting of hospitalizations, injuries and deaths following vaccination.

In 1989, NVIC sponsored an International Scientific Workshop on Pertussis and Pertussis Vaccines and, in 1996, one of NVIC’s major goals was realized when a purified pertussis vaccine was licensed for American babies after a decade and a half of advocacy work. In 1997, NVIC held the First International Public Conference on Vaccination and sponsored the Second International Public Conference on Vaccination on Sept. 8-10, 2000 in Washington, D.C. The Third International Public Conference on Vaccination will be held on November 7-9, 2002 in Arlington, Virginia.

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Read it again: "the need for fluoride depends on overall exposure, including place of residence, diet and oral health habits, etc."

So, it is stating that there is a need, that some good purpose can be served. And that, beyond a certain point, additional intake of fluoride is not needed. Not harmful, but "not needed".

There IS no need. Provide ONE scientific study that points to a NEED for a toxin. There isn't. The flawed research performed by those with an agenda is NOT valid. Perhaps you need a bit more info on what I'm referring to...

The Fluoride Controversy

By Dr. Ted Spence

Fluoride is a very controversial topic, but how controversial I did not realize. The data reveals that fluoride is a chemical toxin. As you can see by my studies and degrees, I place a large amount of confidence in nutritional methods for over coming disease and place little in toxic drugs, synthetic chemicals and especially toxins, like fluoride.

A few years ago, I was asked by the head of our local health department to conduct a review of existing journal research on the toxicity of fluoride with emphasis on its cancer causing potential. I went to the National Medical Library and produced for him some 40 articles on the toxicity of fluoride. When we reviewed them, there was some discrepancy in whether or not fluoride was mutagenic.

Well, half of the articles said that it was and half said that it was not. But it can not be both ways ... We wondered what was wrong. Then the element of bias entered the picture, since Proctor and Gamble has paid for some of the "negative-concluding" research. We were still puzzled.

My only goal is to tell this information to the patients and let them decide. Isn’t that fair ... after all it is their decision? It is the patient’s choice ... isn’t it? The toxicity of fluoride has caused many countries to rethink the fluoride issue and many have rescinded fluoride in favor of the health of their people.

Those banning fluoride are Sweden, Norway, Denmark, West Germany (now unified), Italy, Belgium, Austria, France, and The Netherlands. Despite these retractions of fluoride, the US still presses on with the goal to fluoridate (poison) every community water supply in the United States.

All allopathically-trained dentists are very familiar with the ADA and other "authoritative" positions on fluoride. They rarely mention its toxic potential or the few studies revealing increased tooth decay after fluoride use. The research of Burk and Yiamouyiannis revealed that every major city with fluoride had increased rates of cancer. Not a fair trade for "good looking teeth".

If you don’t want to look at this data, that is your decision. As health professionals, we don’t want to harm patients in any way and fluoride produces great harm. I am referring to taking fluoride internally, where it has been found to cause unscheduled DNA synthesis, sister chromatid exchanges and yes, mutagenic effects on the cells.

These terms may not bother some people at all, but they mean that there will be an increase in cancer after the ingestion of fluoride. Tsutsui, et al found that the addition of fluoride to healthy liver cell, in vitro, could establish changes that can only be described as cancerous.

The ADA’s official position is that this stuff is safe, yet there have been deaths of children in the dentists office due to fluoride, albeit very few. The point I am trying to make is that this is not to be taken lightly. In a letter [to me] from the ADA apologizing for fluoride, that stated, "There are three basic compounds commonly used for fluoridating drinking water supplies in the United States: sodium fluoride, sodium silicofluoride, and hydrofluorosilicic acid."

Now any chemist can tell you that these are not the sodium fluoride we are all told about. Sodium hydrofluorosilicic acid is one of the most reactive chemical species know to man. Its toxicity is known in many chemical circles. It will eat through metal/ plastic pipes and corrode many materials including stainless steel and other metals. It will dissolve rubber tires and melt concrete. This is added to our water to produce "healthy teeth".

Fluoride Does the Following:

inactivates 62 enzymes (Judd)
increases the aging process (Yiamouyiannis)
increases the incidence of cancer and tumor growth (Waldbott/Yiamouyiannis)
disrupts the immune system (Waldbott)
causes genetic damage (Tsutsui, et al)
interrupts DNA repair-enzyme activity (Waldbott)
increased arthritis and
is a systemic poison.

"Fluoride is a highly toxic substance.... "

L P Anthony, DDS editor of the Journal of the American Dental Association - 1944

Funny how times change, but truth does not change.

"....we have very strong circumstantial evidence of systemic toxicity of the so-called absolutely safe concentrate of fluoridated water"

Roy E Hanford, MD, "Where is Science Taking US? reprint from Saturday Review

"Don't drink fluoridated water .... Fluoride is a corrosive poison which will produce harm on a long term basis." Dr Charles Heyd, Past AMA president

Some 61,000 cancer deaths in the US result from fluoridation each year. I repeat 61,000. (Burk and Yiamouyiannis) One study found that fluoride elevates cancer mortality 17% in 16 years in large cities. (from Gerald Judd, PhD) "You have been led to believe the fluorine makes teeth harder. The fact is, it actually makes teeth softer." (George Meinig, a founder of the American Academy of Endodontics)

The US sees a 22% increase in decay every 16 years from fluoride use and a 50% decline in decay every 20 years compared with Finland's 98%, Sweden's 80% and Holland's 72%. And they are non-fluoridated. (Gerald Judd)

My only goal is to tell the truth about the ill-effects of a known toxin. I mentioned the paper being published by the Health Freedom News on the neurotoxicity of fluoride. Fluoride is a potent neurotoxin and this has been known for some time; at least since the early 1940s, well before the fluoridation experiment with Grand Rapids.

Dr Gerard Judd, PhD (chemistry), [ emeritus Manhatten project] found that fluoride can inactivate 62 enzyme systems. As a naturopath, nutritionist and master herbalist, I cannot endorse a substance that has known detrimental effects.

Geoffrey Smith stated, "Recent studies suggest that fluoride may be genotoxic." (p 79, Smith) And added, "There is now a substantial body of evidence suggesting that fluoride is mutagenic." (p 93, Smith) Gibson also noted, "Fluoride is one of the most toxic inorganic chemicals in the Earth's crust, ... However, with increasing experience, doubts about both safety and efficacy have arisen." (p 111, Gibson)

And he added, "A possible link between fluoridation of public water supplies and an increase in the cancer death rate has been debated for over 20 years and there is now no doubt that fluoride can cause genetic damage." (p 111, Gibson)

Gibson noted, "Inhibitory effects of fluoride on different enzyme systems have been demonstrated." (p 111, Gibson) And, "A section of the population may therefore be at risk of compromised immune system function from water fluoridation schemes." (p 112, Gibson)

Get the drift; fluoride is not everything it is cracked up to be. Mutagenic, enzyme inhibition, genetic damage, increased cancer rates, genotoxic and controversial, all describe fluoride.

Tsutsui et al noted, a significant increase in chromosome aberrations at the chromatid level, sister chromatid exchanges, and unscheduled DNA synthesis was induced by NaF in a dose- and timedependent manner.

These results indicate that NaF is genotoxic and capable of inducing neoplastic transformation of Syrian hamster embryo cells in culture." (p 938, Tsutsui et al) There, you can see the controversy for yourself. Fluoride is toxic, fluoride is non-toxic; fluoride causes cancer, fluoride doesn't cause cancer. Who do we believe?

The fluoride controversy comes down to

... Who Do We Really Believe?

Here's two articles on mutations caused by fluoride:

Sodium Fluoride-induced Morphological and Neoplastic Transformation Chromosome Aberrations, Sister Chromatid Exchanges, and Unscheduled DNA Synthesis in Cultured Syrian Hamster Embryo Cells, Takeki Tsutsui, Nobuko Suzuki and Manabu Ohmori, Can Res, 44:938-941, 1984 (March)

Sodium Fluoride-induced Chromosome Aberrations in Different Stages of the Cell Cycle: A Proposed Mechanism, Marilyn J Aardema, et al, Mutation Research, 223:191-203, 1989

The titles say it all.

Therefore, because of this controversy my feelings on this matter is that is should be up to the patient. They need both sides of the story to make an "intelligent" decision. I only mean to give them the other side. References are cited for your use and reading enjoyment.

The EPA found that at 2 ppm salmon were sterile, yet at 1 ppm it is placed in our water supply. [Dr Richard Foulkes] Fluoride only helps [if it helps] children up to age 12. Yet, everybody is "forced" to drink it. Oscar Ewing, who pushed fluoride in the legislature, told the senators not to drink it.

The last thing I would say it that by endorsing fluoride you totally eliminate the real prevention of tooth decay ... good sound nutrition. Tooth-brushing [important as it is] does not stop tooth decay.

Fluoride [a toxic] does not stop rampant tooth decay. [Fluoride only hardens to outer surface of the enamel and may prevent calcium from being deposited when a tooth is re-mineralized.] Nutrition stops tooth decay. I have developed a nutritional supportive program which will totally stop tooth decay in less than two weeks.

I have watched many children go from all 20 carious deciduous teeth, to 20 ebernated [hardened] teeth, which are non-painful and hard as rock. I have never seen fluoride do this [after 21 years of dentistry] and fluoride is not even a part of my caries prevention program.

Ted H Spence, DDS, ND, PhD/DSc,MH

References:

Waldbott, George, MD, Fluoride: The Great Dilemma, 1978, Coronado Press, Lawrence, KS

Yaimouyiannis, John, Fluoride: The Aging Factor, 1993, Health Action Press, Delaware

On Neurotoxicity:

Varner, J A, et al, "Chronic Administration of Aluminum Fluoride or Sodium Fluoride to Rats in Drinking water: Alterations in Neuronal and Cerebrovascular Integrity", Brain Research, 784(1-2):284-298, 1998, 1998, Feb 16.

Isaacson, R L, et al, "Toxin-Induced Blood Vessel Inclusions Caused By the Chronic Administration of Aluminum and Sodium Fluoride and Their Implications in Dementia", Ann NY Acad Science, 825():152-166, 1997, Oct 15.

Varner, J A, et al , "Chronic Aluminum Fluoride Administration, Part I: Behavioral Observations", Behavior Neural Biology, 61(3):233-241, 1994, May.

Burgstahler, A W, Colquhoun, J, "Neurotoxicity of Fluoride", Fluoride, 29:57-58, 1996 and

Li, X S, Zhi, J L, Gao R O, "Effects of Fluoride Exposure on the Intelligence of Children", Fluoride, 28:182-189, 1995 and

Mullenix, P J, et al, "Neurotoxicity of Sodium Fluoride on Rats", Neurotoxicity and Teratology, 17:169-177, 1995 and

Zhao, L B, et al, "Effect of Fluoridated Water Supply on Children’s Intelligence", Fluoride, 29:190-192, 199


©Copyright 1997-2002 Dr. Joseph Mercola. All Rights Reserved. This content may be copied in full, with copyright; contact; creation; and information intact, without specific permission, when used only in a not-for-profit format. If any other use is desired, permission in writing from Dr. Mercola is required.

Is Fluoride Really As Safe As You Are Told?

Part 1 of 3

Fluoride is added to the water supply of most American cities for the ostensible purpose of dental hygiene. The reader will be amazed to find out that such a thing is not only unlikely, but actually the reverse of the ongoing reality

The U.S. has been fluoridating drinking water for so many decades that we hardly think about it. Very few articles appear about fluoridation in newspapers and magazines any more.

At least chlorine will evaporate from a glass of water if you let it sit for an hour or so. No such luck with fluoride. Even cooking, food processing, filtration, or digestion doesn't remove fluoride. Goes right up the food chain. Accumulates in fat cells.

This Is No Accident.

What would you do if you suddenly found out that fluoride was not safe at all, but was actually a carcinogenic industrial waste?

What would you think if you suddenly found out that fluoride doesn't stop tooth decay at all, but actually causes teeth to rot and crumble, and by the same mechanism also causes osteoporosis?

And after you found out all this, would it surprise you that all federal health agencies have known these facts for years, but have been controlled by the political interests of the nuclear arms, aluminum, and phosphate manufacturers to keep it a secret?

Why would they do that? So that, in the total absence of scientific proofs, a toxic industrial waste could be passed off on the public as a nutrient with necessary health benefits, to the tune of $10 billion per year. Or more.

Is a deception of this magnitude possible for the sophisticated, discerning American public? Perhaps Lance Ito could answer a question like that.

Let's start at the beginning.

What Is Fluoride?

Fluorine is an element. It is a gas, never occurring in its free state. In microscopic amounts complexed with other minerals, it is often listed as a trace mineral, a nutrient for human nutrition.

This has nothing to do with fluoride or fluoridation. The fluoride added to 90% of drinking water is hydrofluoric acid which is a compound of fluorine that is a chemical byproduct of aluminum, steel, cement, phosphate, and nuclear weapons manufacturing.

Such fluoride is manmade. In this form, fluoride has no nutrient value whatsoever. It is one of the most caustic of industrial chemicals. Fluoride is the active toxin in rat poisons and cockroach powder.

Hydrofluoric acid is used to refine high octane gasoline, to make fluorocarbons and chlorofluorocarbons for freezers and air conditioners, and to manufacture computer screens, fluorescent light bulbs, semiconductors, plastics, herbicides, -- and toothpaste.

It also has the ability to burn flesh to the bone, destroy eyes, and sear lungs so that victims drown in their own body fluid."

Once in the body, fluoride is a destroyer of human enzymes. It does this by changing their shapes. You'll remember from the Enzymes chapter (www.thedoctorwithin.com) that in human biochemistry, thousands of enzymes are necessary for various essential cell reactions that take place every second we're alive. (Howell) Without enzymes, we'd die instantaneously.

Once in the body, fluoride is a destroyer of human enzymes. It does this by changing their shapes. In human biochemistry, thousands of enzymes are necessary for various essential cell reactions that take place every second we're alive. Without enzymes, we'd die instantaneously.

Enzymes trigger specific reactions in the body. One way they do this is by having the exact shape necessary, like a key in a lock.

Fluoride Changes The Shape Of The Enzymes So That They No Longer Fit.

Since enzymes are proteins, once they've been changed, they're now foreign-looking. The body now treats them as invaders, even though they're part of that body. This is known as an autoimmune situation - the body attacks itself.

Another way to look at it: enzymes are long-chain proteins held in certain shapes. Hydrogen bonds are the velcro strips that hold the enzyme in a certain shape. Fluoride comes along and hydrolyzes the enzyme: cuts the Velcro strips away. The shape collapses. No more enzyme; now just a foreign protein.

Starting Point

The most thorough explanation of the origin, action, diseases, and politics of fluoride was presented in a book called Fluoride the Aging Factor by John Yiamouyiannis, PhD.

This book is the result of 25 years of research and working behind the scenes of the fluoride phenomenon. Big money generally means big monkey business, you may have noticed by now, and fluoride is right up there.

Dr. Yiamouyiannis was the science director of the National Health Federation. He then went on to head the Safe Water Foundation. Dr Y can tell you all about monkey business.

No one can comment intelligently about fluoride in the U.S. without dealing with the issues raised in his pivotal book. It is simply a review of the literature on fluoride up to 1994.

Dr. Y starts by citing hundreds of international studies of fluoridation that have been conducted all over the world since the 1930s. After awhile, there seem to be just two types:

Studies that were really looking to find out about fluoride
Studies that were trying to cover up what had already been discovered

Examples Of The Former:

Taylor Study, University of Austin: fluoride concentration of 1PPM (parts per million) increases tumor growth rate by 25%

Fluoride is more poisonous than lead, and just less poisonous than arsenic - Clinical Toxicology of Commercial Products -- 1984

"A seven ounce tube of toothpaste, theoretically at least, contains enough fluoride to kill a small child." - Procter&Gamble, quoted in Fluoride the Aging Factor p14

Fluoride supplements should not be given to children under three years old - 1992 Canadian Dental Association Proposed Fluoride Guidelines, Dr. Limeback

Fluoride Accelerates Your Aging Process

Austrian researchers proved in the 1970s that as little as 1 ppm fluoride concentration can disrupt DNA repair enzymes by 50%. When DNA can't repair damaged cells, we get old fast.

Fluoride prematurely ages the body, mainly by distortion of enzyme shape. Again, when enzymes get twisted out of shape, they can't do their jobs. This results in collagen breakdown, eczema, tissue damage, skin wrinkling, genetic damage, and immune suppression. Practically any disease you can name may then be caused.

All systems of the body are dependent upon enzymes. When fluoride changes the enzymes, this can damage:

immune system
digestive system
respiratory system
blood circulation
kidney function
liver function
brain function
thyroid function

Things wear out too fast - the young body becomes old.

The distorted enzymes are proteins, but now they have become foreign protein, which we know is the exact cause of autoimmune diseases, such as lupus, arthritis, asthma, and arteriosclerosis.

Collagen Is The Body's Glue and Fluoride Ruins It

That's not just a metaphor; when collagen breaks down, tissues simply lose their substance, their framework. Fluoride dissolves the body's glue simply by preventing new collagen from being formed.

DR Y gives a masterful explanation of fluoride's disruption of collagen. Not only is the collagen incorrectly formed, it is wrongly mineralized.

Some collagen, like bones and teeth, should be mineralized in order to give it hardness. Other collagen structures, like ligaments, tendons and, and muscles, should not be mineralized, in order to keep them flexible and resilient.

Fluoride mineralizes the tendons, and muscles and ligaments, making them crackly and painful and inflexible. At the same time fluoride interferes with mineralization of bones and teeth, causing osteoporosis and mottling or dental fluorosis.

Fluoride Ruins Your Teeth

Wait a second here! I thought that was the whole reason why we fluoridated water in the first place - to prevent cavities and build strong teeth, right?
Wrong again. And this is where politics and dog-wagging have eclipsed science. DR Y gives an exhaustive review of the scientific literature of the past 40 years proving beyond a reasonable doubt that fluoride interferes with tooth formation, causing permanent discoloration and actual crumbling.

The process whereby teeth are discolored and crumble from fluoridation is know as dental fluorosis.

The US Public Health service has known since the research of its own Dr. HT Dean in 1937 that as fluoride levels rose, so did the percentage of children with dental fluorosis, in a study of 15 major American cities.

The same findings were evident in a University of Texas study comparing dental fluorosis in children who lived in fluoridated and unfluoridated areas of Texas.

Dr. Segretto found a 35% higher incidence of fluorosis in children who drank water with fluorine concentration of 1-1.4 PPM, compared with those whose water was in the .3 PPM range. This little study was written up in the Journal of the American Dental Association.

Yiamouyiannis goes on and on, citing one peer-reviewed study after another, all coming to the same inescapable conclusion:

The More Fluoride In The Water, The More Tooth Malformation And Discoloration.

It's beyond controversy, when you view these studies from all over the world - New Zealand, India, Denmark, England, Ireland, Italy, Illinois - same finding. Even with this consistent finding across the board, the standard level of fluoridation recommended for dental health in the US is 1 part per million.

How Is This Possible?

A major gain for antifluoridation happened in the past few years, which most people haven't even noticed. The FDA required all toothpaste manufacturers to print a warning on the label that if more than a pea-sized amount of toothpaste is swallowed, the local Poison Control Center should be notified.

The American Dental Association and other defenders of fluoride have testified and continue to insist that dental fluorosis is a "cosmetic condition" and is not a health issue!

Permanent malformation of the teeth is a little more serious than cosmetic - but even if it weren't, how can a additive whose only alleged purpose is to benefit teeth destroy teeth?? In their current website, the ADA actually challenges this FDA warning on toothpaste labels, saying that it is unnecessarily strict.

Paul Connett, PhD explains that spots on the teeth and dental fluorosis are just an indication of damage to other parts of the body:

"The teeth are windows to what's happening in the bones."

Fluoride And Osteoporosis

Bone is collagen. We already saw how fluoride disrupts the formation of enzymes necessary for collagen production. So it's no wonder then that the thin brittle bones characteristic of osteoporosis are the result of fluoridation.

This is no false claim.

DR Y cites the 1990 study of 541,000 cases of osteoporosis that found a definite connection between hip fractures in women over 65 and fluoride levels. The study was written up in JAMA. Several other major studies are cited, massive amounts of research, again all reaching the same conclusion -

the undeniable correlation of fluoridation with osteoporosis and hip fracture in the elderly.

Bone Is Living Tissue.

It is constantly being replaced with new cells, and having old cells removed. Bone building is a finely balanced, complicated process. Fluoride has been known to disrupt this process since the 1930s. Dr. Alesen, who was the president of the California Medical Association, clearly explains what fluoride does to bone formation.

He cites dozens of international scientific studies proving beyond a shadow of a doubt that fluoride has caused thousands of cases of osteoporosis, skeletal thinning, fractures, "rubber bones," anemia, and rickets.

Fluoride also causes osteoporosis by creating a calcium deficiency situation. Fluoride precipitates calcium out of solution, causing low blood calcium, as well as the buildup of calcium stones and crystals in the joints and organs.

Dozens of other studies, like the Riggs study in the 1990 New England Journal of Medicine, showed that fluoride treatment of osteoporosis in the elderly actually increases skeletal fragility, i.e., more fractures.

It's the same mechanism at work: incorrect mineralization, as we saw above. Thin old bones lose calcium; young bones age too rapidly by over-mineralization.

Using fluoride as a treatment for diseases like osteoporosis has always been a particularly dumb idea, because of side effects known beforehand:

general arthritis
stomach pain
nausea
vomiting
bone spurs
bone inflammation
kidney fibrosis
dental fluorosis

Other mineral contaminants like lead and strontium-90 are damaging to human bone just by means of their occupying space where they don't belong. They are inert. The difference with fluoride is that it is biochemically active. With all the diseases caused by fluoride, the common thread is

"…virtually all these ill effects can be traced to the effect of fluoride on enzymes or proteins, as well as a possible direct effect on the DNA molecule itself."

Above we saw how fluoride changes the all-important shape of enzymes, thereby rendering them not only useless, but actually foreign antigens.

Cancer And Fluoride

By now we all know how cancer begins with one cell whose inner blueprint - its DNA - has been screwed with.

Remember those Velcro hydrogen bonds? Guess what other shape they hold together. The double helix - DNA. This turns out to be the exact mechanism of fluoride as a carcinogen.

Austrian and Japanese researchers both found that a concentration of 1 PPM fluoride causes disruption of the body's ability to repair its own DNA. Without this most basic cell function, cancer is promoted, and tumor growth is accelerated.

That's standard fluoride level in US city water: one part per million.

On p. 65 of his book, Dr. Yiamouyiannis provides an amazing chart of some 19 major scientific studies conducted in universities all over the world, together proving beyond a doubt that fluoride causes genetic damage.

End of story.

Except that on p 68, there is another list of world studies proving the same thing with plants and insects - genetic alteration from fluoride.

Chief chemist of the National Cancer Institute, Dr. Dean Burk when confronted with mountains of data, stated before Congress:

"In point of fact, fluoride causes more human cancer death, and causes it faster than any other chemical."

- Congressional Record 21 July 1976

Can That Be Misconstrued?

Burk and Yiamouyiannis completed a monumental research project in 1977 in which they compared cancer death rates in 10 fluoridated and 10 non-fluoridated US cities between 1940 and 1970. The results are on p75 of Fluoride the Aging Factor.

The unmistakable fact is that the graph shows that for the first ten years (1940-1950), when none of the 20 cities fluoridated, the average cancer deaths were virtually identical. But after 1950, there is a major increase in cancer deaths in every single one of the fluoridated cities, while the nonfluoridated cities remain clustered together at a much lower level of death.

They actually put a number on it:

"…30,000 to 50,000 deaths each year from various causes may now be attributable to fluoridation. This total includes 10,000 to 20,000 deaths attributable to fluoride-induced cancer every year."

These findings were first confirmed, then denied by the National Cancer Institute (what a surprise). Finally the research was upheld as valid in two separate state courts, Pennsylvania and Illinois.

Ask yourself, why are findings of a scientific study being disputed in court? The usual pattern whenever valid research threatens big money.

Another study by the New Jersey Health Dept., cited by Dr. Y, found a 50% increase in bone cancer among young men in fluoridated areas. (Cohn)

Dr. William Hirzy, an officer in the EPA explains:

"Fluoride is a broad-spectrum mutagen. It can cause genetic damage in both plant and animal cells."

Once again, this is just the tip of the iceberg. Hundreds of scientific studies conducted and reported in the most credible universities and agencies throughout the world for the past 25 years have found an unmistakable correlation between fluoridation and cancer deaths. Even the professional opinion makers can't just make all this data vanish.

All they can do is what they're trained to do: change the subject. And keep repeating how safe and effective fluoride is.

Brain Damage = Low IQ

Penetrating observation. The earliest reference to brain disruption from fluoride exposure is found in a recently declassified secret Manhattan Project memo (1944):

"Clinical evidence suggests that C616 [uranium hydrofluoride] may have a rather marked central nervous system effect with mental confusion, drowsiness and lassitude…"

How can all these studies be dismissed and ignored? Many of them are from the most prestigious of scientific journals. And the message has been consistent for the past 40 years - fluoride is a poison.. What kind of power can contradict such a cogent, overwhelming body of work?

Only one thing -very good -- $$$$$$$$!

Got it on your first guess!

So Then Why Are We Fluoridating, For The Last 60 Years?

Unrestricted research into almost any area involving health care is really a tiresome business - it's the same boring story over and over:

A Toxin in Search of A Market.

First a chemical is created, then an angle is figured out on how to mass market it. Then a disinformation program is put into place to create a permanent smokescreen for the actual scientific data.

As we saw with ADD, antibiotics, the history of pharmaceuticals, HRT, heart drugs, chlorination, and now fluoridation - the pattern is consistent.

With billions of dollars in play, the chemical industry can afford to choreograph its two most willing marionettes: the media and the medical profession.

I didn't make this up; I wish it were otherwise. It's embarrassing to be a human when you find out what's been going on.

But we digress.

Fluoridation. A certified poison, by all the government agencies and scientific agencies cited above. Where does the money come in? Toxic disposal. The rise of the EPA since the 1970s. The increase in environmental consciousness as a political tool for creating the illusion of safety in recent decades.

Here's the short version: fluoride is a toxic byproduct in the manufacture of nuclear arms, aluminum, cement, steel, and phosphates.

Millions of tons of this poison are produced every year. Imagine the cost of containing and disposing of those mountains of waste every year. It's in the billions.

But what if lobbyists from these industries could present "scientific studies" paid for by the industries, and provide for a continual stream of media presentations about the health benefits of fluoride, and create unimaginably lucrative positions for "research" and "education" within the American Dental Association and the AMA, and do all these things in a consistent and unending way, year after year?

What are the economic advantages of that? Simple: instead of paying money to dispose of toxic waste, money could now be made by selling fluoride to the water companies of the nation.

They'll use the public water supply as a sewer for industrial wastes. And now with these new billions added instead of subtracted, there's plenty to go around, for everyone involved. Out of the Red, into the Black.

Somewhere Machiavelli smiles.

Dark Alliance

Up until 1931, the American Dental Association and the US Public Health Service recognized that fluoride caused dental problems, and that every effort should be made to remove such contamination from drinking water. (Fluoride the Aging Factor, p 140)

By 1980, the ADA's tune had changed a little:

"…there is no evidence implicating naturally occurring fluorides as a health hazard even at eight parts per million."- ADA News 24 Mar 1980

Following this? In the face of all the decades of our best research, this arrogant and groundless pronouncement, by the profession to whom we have entrusted our teeth, is saying that our water could have 8 times as much fluoride as it has now, and still be perfectly safe!

The Players: ALCOA Aluminum, mega-giant producer of aluminum, was founded by Andrew Mellon, who was also appointed Secretary of Treasury, since he seemed to know something about money.

ALCOA funded a top research facility known as the Mellon Institute. In 1931, a Mellon Institute report by Gerald Cox suggested that 1 PPM fluoride added to drinking water would be good for the teeth. That was it. No studies, no comparisons, no data. All previous research studies had shown that fluoride was toxic.

Stay with me now. The US Public Health Service (USPHS) at that time was under the jurisdiction of the Secretary of Treasury - Andrew Mellon, who also owned ALCOA.

The USPHS sponsored some research put out by their own Dr. HT Dean, manipulating data so that it "proved" that this same figure of 1 PPM resulted in reduction of tooth decay. So now there were two studies, one by Cox and one by Dean, both funded by agencies controlled by ALCOA, both supporting this arbitrary figure of 1 PPM fluoride that should be added to the water to lower tooth decay.

Next problem: sell it to the American Medical Association and the American Dental Association.

This took years. Even in 1943, an article in JAMA described fluoride as a poison that damaged enzyme systems even at a concentration of 1 PPM. The article showed concern about 25,000 tons of fluorine released into the atmosphere every year from the phosphate fertilizer industry. (JAMA, Sept 18, 1943).

The following year Journal of the American Dental Association ran another article warning that fluoridated water caused osteoporosis, goiter, and spinal disease. They stated that "the potentialities for harm far outweigh those for good." (JADA, 1 Oct 1944)

So how did fluoridation get started then, with all this information - thousands of negative scientific papers and only two favorable studies? ALCOA money, that's how.

In 1944, ALCOA hired an attorney named Oscar Ewing at a salary of $750,000 per year. That same year Ewing was appointed to the Federal Security Administration. The USPHS was a division of the Federal Security Association. So now ALCOA's boy was in a position to control the policies of the Public Health Service.

Ewing chose his PR man for fluoridation: Edward Bernays, the nephew of Sigmund Freud.

Please look for the continuation of this article in my next issue.

References

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Disclaimer - Newsletters are based upon the opinions of Dr. Mercola. They are not intended to replace a one-on-one relationship with a qualified health care professional and they are not intended as medical advice. They are intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.

Is Fluoride Really As Safe As You Are Told? - Part II

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Special Report Winter 2002

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About the Editor

The Fluoride Controversy