Since she voted no on the cloture vote, she’s virtually assured to vote no on the final vote.
Is it possible to somehow primary out Sen. Murkowski when her current term ends? Never-Trumpers at this point in the game are more vicious little venomous snakes than outright opposition.
Calling Sen. Murcowski a “Republican” at this juncture is like the Democrats pointing to Robert Mueller and calling him a “Republican”. Anybody can go to the county courthouse and list their affiliation as they darned please, but that does not make you a “Republican” in anything but name only.