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I take 1000 am pm. Changing today cause I am peeing out $$. Just like when I was drinking beer. May 1/2 these 1000 tabs 2 times a day and switch to 200 tabs if available multi times a day. Found this at the Linus P site: Depletion-repletion pharmacokinetic experiments demonstrated that plasma vitamin C concentration is tightly controlled by three primary mechanisms: intestinal absorption, tissue transport, and renal reabsorption (6). In response to increasing oral doses of vitamin C, plasma vitamin C concentration rises steeply at doses between 30 and 100 mg/day and reaches a steady-state concentration (60 to 80 μmol/L) at doses of 200 to 400 mg/day in healthy young adults (7, 8). One hundred percent absorption efficiency is observed when ingesting vitamin C at doses up to 200 mg at a time. Once plasma ascorbic acid levels reach saturation, additional vitamin C is largely excreted in the urine. Notably, intravenous administration of vitamin C bypasses absorptive control in the intestine such that very high concentrations of ascorbic acid can be achieved in the plasma; over time, renal excretion restores vitamin C to baseline plasma levels (9) (see Cancer Treatment). Due to the pharmacokinetics and tight regulation of plasma ascorbic acid, supplementation with vitamin C will have variable effects in vitamin C-replete (plasma levels near saturation) versus sub-optimal (plasma levels <50 μmol/L), marginally deficient (plasma levels <28 μmol/L), or severely deficient (plasma levels <11 μmol/L) individuals. Scientific studies investigating vitamin C efficacy to prevent or treat disease need to assess baseline vitamin C status before embarking on an intervention or statistical analysis (6, 11-13). For a more detailed discussion on the bioavailability of different forms of vitamin C, see the article, The Bioavailability of Different Forms of Vitamin C .