A filibuster is a refusal to end debate and call the question. If the vote never occurs, you never lose. The cloture vote exists, on the issue of calling the question - and a cloture vote can be called any time (after, IIRC, a preset minimum time). But the cloture vote fails if you dont get 61 votes.
So, anything that goes to vote is by simple majority.
The vote can be held up by talking nonstop before the vote.
What’s it called when they limit each speaker’s time?