Podesta would be a disaster as Secretary of State.
All of her picks would have been a catastrophe.
ca·tas·tro·phe
noun
noun: catastrophe; plural noun: catastrophes
an event causing great and often sudden damage or suffering; a disaster.
“a national economic catastrophe”
synonyms: disaster, calamity, cataclysm, holocaust, havoc, ruin, ruination, tragedy; More
adversity, blight, trouble, trial, tribulation
“the flood of ‘82 was the worst catastrophe in the town’s history”
•the denouement of a drama, especially a classical tragedy.