I’ve got a 4 inch Blue and a 6 inch stainless Python and neither of these pistols are showing any timing problems. The 4 inch was built in 1970 and has around 1500 rounds through it with most of those during yearly qualifying when I was with the SO. Most of those were standard 38 special, my duty round was the 357 Mag 125 grain loads. The 6 inch I carry daily on the ranch and it see all the heavy use with 140 and 158 grains Mag loads. I’m guessing it’s seen close to 1000 rds. While I love the smooth double action on the Colts the single action goes to my 4 inch Model 19 and the 6 inch 686. The 686 is by far the more accurate of all the pistols mentioned, plus it’s built to handle the heavier loads that seem to be the rage.
My model 19 has about 60K rounds through it and it’s still in time.