His career is over. Trump supporters are at least a supermajority of Republicans, and few will ever support or trust Ryan again.
Might as well attack Paul rino because this resonates with most Republicans and populists throughout the nation. Ryan represents the globalist establishment and he will not find support outside WI. Ryan will keep his seat because of sentimemetal reasons and the strong establishment constituency in WI. Trump can write off WI as it hasn’t voted GOP since Reagan.