The Whiskey was plainly unconstitutional and the opponents where represent and had means to Appeal and repeal it. It is after all a Republic not a democracy.
The Whiskey Act was a preview of the abuses to come, many following the same pattern - populous, wealthy northeastern states imposing their will on those with less political influence.
This same pattern continues today, right up to imposing acceptance of transgenders in the ladies’ restroom. More diktat from wealthy northeastern states being imposed by force on wide swaths of the country that don’t want it.
It’s a fundamental flaw in the model. A Republic is not supposed to allow majorities to impose their will, willy-nilly, on the whole of the population. Yet under the Constitution, exactly that had started occurring from the very earliest years.