Nope. They'll simply up the volume of their shouting of "Trump hates women, Trump is racist, Trump hates gay people, Trump hates immigrants. Etc.".
That will suffice for virtually every Democrat.
Well, there may be that little issue of Hillary soon spending a lot of time in court facing multiple felonies.
They can turn up the anti-Trump rhetoric all they want, but if they don’t have a candidate they’re not getting anywhere.