Premarin has been linked to strokes. The connect is so well documented my doctor took me off Premarin a good ten years ago since I am at high risk for strokes.
Premarin is accurately named. pregnant mare’s urine. And doctors want you to put it into your liver straight from the mouth. Strokes, cancer. Disgusting malpractice. Nothing wrong with supplement hormones but it can’t be oral. Transdermal, vaginal, or injection, small doses. You will be fine.