On the other hand there are passages in the old testament that state the land of Egypt will be inhabitable for 40 years. Ezekiel 29:9-21 And it also tells of Damascus, the oldest city, still not destroyed yet, becoming a ruinous heap. Isa 17:1.
Destroy Jerusalem, Dome of the Rock goes with it as well as Church of the Holy Sepulchre. Basically a nuke strike against Israel is war on both Judaism and Christianity, since Islam will see the Dome of the Rock being destroyed as something that Allah willed.
This means a strike will either be north or south. North and that destroys Syria and Lebanon. South and you take out Egypt. My bet would be south as it leaves a corridor for Iran to attack through Syria and Lebanon.