“Is smoking plus mold a bad interaction?”
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Mold is worse than smoking IMHO.
I grew up in a non-smoking household and suffered from asthma for years. Emergencies in the middle of the night were frequent.
My 5 kids were raised in a household where both parents smoked, None of them got asthma.
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Baraq’s lake adjacent mansion in Chicago is about 100 yrs old.
So you know it’s got mold.