Yes, I do. Colorado is perfectly capable of exercising its own police powers. If you ship it out of state, then the feds can get involved.
The Commerce Clause gives Congress the power "To regulate commerce with foreign nations, and among the several states, and with the Indian tribes." It is one of the enumerated powers. It does not give Congress the power to regulate all commerce in any state.
Once you accept that Congress has the power over any commerce in the U.S., then the federal government is no longer a government of enumerated powers.
Libertarians are always saying drug interdiction is an abuse of the commerce clause, but I have always maintained that the authority to interdict drugs comes from the same place as the authority to interdict Nuclear, Biological, and Chemical weapons.
Or do you dispute the idea that the Federal government has the authority to interdict dangerous substances, especially those coming from outside our borders?