The only way an opposition party (and by this I mean a political party in a minority position in a legislative body) to wrest control away from the ruling party is by presenting a strong, unified voice with specific ideas about how they’d govern better. A big problem the Republicans face is that they have too many Senators who have already been in a position to deal with many of the key issues at hand, and have never demonstrated that they are willing or able to deal with them. This is why they even have long-time incumbents at risk in a political cycle where the opposition party would normally be in a strong position.
True, but we have gone beyond that now with bureaucratized socialism, and s5rict enforcement thereof. Going to be difficult if not impossible to break this, I am afraid...