There actually needs to have been hostility. The early settlers of the NC colony were largely forced out of someplace else, Virginia, Maryland, Pennsylvania or even Scotch-Irish landing on the coast and working their way inland up the rivers and creeks. They were a very mixed bag, from the British Isle across most of Western Europe and into Central. All sorts of religious sects.
They got on well enough, and also got on well enough with the native tribes to the point that most old families have some native ancestry. Overbearing and/or corrupt officialdom has always been the source of any blowup, and there have been more than the history books generally record. Factions form, some religious sects are more prone to supporting establishment, some had and still have an ingrained distrust. And there you go.
It’s still there, albeit getting harder to encounter with the influx of people from elsewhere, most of whom seem rather too enamored of officialdom themselves. It’ll likely flare up in some way again, I’d say in the mountain counties, most of which are the reddest of the red counties in NC. Then, you have the cities there turning into San Francisco east.
All I know of early NC is that it was the first state to reject ratification of the constitution. I don’t bring it up as a negative, it just is. Your screen name implies why.
Two of my ancestors, a father-son duo, were North Carolina Quakers, presumably abolitionists, who volunteered for the Union Army in the Civil War. There were three Union N.C. regiments. After the War they moved to a Quaker settlement in Indiana. I’ve always assumed they weren’t very welcome in N.C. after the War.