I have to admit that is probably what I would do, because I am a hothead and don't want anyone to take our stuff. Most of the time they would probably run off if they weren't cornered after they heard you chambering a round.
But I have heard that uder most circumstances... the safer more reasonable thing to do would be to make sure that you and your family are safe in a defendable hidden place of cover then wait for the intruder(s) to come to you. Then blow them to pieces before they have a chance to come up with a plan to disarm and kill you and your family.
Understand - but the best defense is also a good offense - take the fight to the enemy.
On the other hand, I have never fired a shot at another human being - so, do I let the adrenalin take over while I'm still in attack-mode, or seek an easier, softer way?
I've thought long and hard on that - guess I really don't know until it's time....