I guess it depends on what knowledge is forbidden. In my mind, cloning and "creating" hybrid life forms by DNA mixing would most likely fall into the forbidden category. But I don't believe astronomy and the study of the universe is forbidden.
Unfortunately the Fall happened; fortunately we were given some moral power so we can choose what is probably okay and what ought not be done. Human cloning ought not be done. There's a lot of things we can do that we ought not. A couple of ancient poets, Coleridge and Wordsworth, commented on some even more ancient philosophers mentioning that wisdom is mainly choosing to not do.
Cloning, etc. is not forbidden, just cloning of humans. Anything that dehumanizes the alive, from newest expression (as in conception) to old age, is wrong for the human race. The rest of creation was given for us to have dominion over. Cloning and stem cell exploitation of other species is a great way to help the human race remain alive and superior. Cloning and exploitation of human embryonic beings for their body parts is a good way to destroy our position and trash our species. Such exploitation and dehumanization isn't necessary in the long run. We're smarter than that, hopefully.