Lung Cancer Vaccine Study Produces 'Exciting' Results

The Scotsman ^ | 2/19/04 | Stephanie Busari

[qam1]

A leading British scientist today hailed pioneering new research into lung cancer as “promising and exciting”.

Dr Richard Sullivan, Head of Clinical Programmes for UK Cancer Research said an experimental vaccine that wiped out lung cancer in some patients in the US was “encouraging”.

The three-year experiment was carried out on 43 lung cancer sufferers by researchers at Baylor University Medical Centre, Dallas.

Each patient had cells from their tumours injected into their arm and leg every two weeks for three months during the experiment.

A gene called CM-CSF was placed into the cancer cells to change the surface of the cells to help the body identify them as cancerous.

The body’s immune cells soon began to recognise, attack and destroy the cancer cells in the lung.

The cancer disappeared in three of the 33 advanced stage patients, while in the rest, the disease remained stable.

For the 10 patients who were in the early stages of their cancer, the vaccine did not make much difference against the cancer.

Dr Sullivan said the vaccine was a breakthrough in the treatment of lung cancer which can be very difficult to treat.

“Lung cancer treatment is a big problem,” he said. “It’s an aggressive cancer that takes years to come up.

“Chemotherapy is very toxic and to kill the cancer, you often end up killing the person.

“Getting the immune system to recognise the lung cancer is an exciting prospect. It is very promising, there’s no doubt about it.”

But he added that the small scale of the sample used meant it would have to be carried out again on a larger population.

“This is a small trial, it needs to be replicated in a large study before we can be sure that it will be beneficial to everybody and is not just a fluke.

“You can get results by chance which have nothing to do with the reality.”

[qam1]

PING

[July 4th]

Smoke up, America!

[tbird5]

does this mean I don't have to quit?

[qam1]

Smoke up, America!

Oh definitely, Smoking prevents Alzheimer's and Parkinson's disease both of which are very costly, If Lung cancer is taking out of the equation then to save Medicaid/Medicare money people should be encouraged to smoke.

[Gabz]

I will put money on it the antis will fight tooth and nail to keep this from ever becoming reality.

These scientists are going find their funding sources drying up one by one.

Look at what happened to the researchers in California studying lung cancer and second hand smoke - after 38 years of a 40 year study the numbers were showing that there is little risk of lung cancer because of SHS exposure - they lost their funding.................

[Rome2000]

C225,the IMCLONE drug that the FDA denied expedited approval, resulting in the Martha mess,works similiarly.

My father was diagnosed with stage IV NSC 3 years ago, and took Erbitux for a year.

No spread as of this time.

They distill it from Mice.

[SouthernFreebird]

Hot damn!..... I been quit for 3 years now, I want a cigarette!

[Dustin DeNiro]

I have a problem. In the small test, NOBODY GOT WORSE. And a high fraction GOT BETTER. Why, then, do we have to wait a decade or so for tests to show that it helps everyone? If your buddy want to try this (it's an autogenous vaccine), why can't he bloody do it?

[cajungirl]

It may be possible to get it prior to FDA approval. Seems to me with lung cancer you have little to lose as far as trying this out. With Melanoma I think they are doing this with good results. Such good news, wish they would hurry up on Altzheimers before I get it!

[zip]

ping

[backhoe]

With Melanoma I think they are doing this with good results.

That's very interesting- when my late first wife developed melanoma in 1980, Siegler at Duke was showing such good results that we elected to try immunotherapy. She passed away from other causes, and my attention drifted away from the subject, but it seems to my recollection that other treatments became more favored for a while. The pedulum always seems to swing between alternatives.

Many years ago ( again, from memory, with its limits ) Coley's Mixed Toxins- a primitive type of vaccination treatment, using a vaccine developed from the patient's own tumor cells, as well as from other tumors, was used with wildly variable results. Some supposedly incurable cancers were wiped out- in some patients- while others were lethally accelerated. Thus it fell out of favor.

[qam1]

I have a problem. In the small test, NOBODY GOT WORSE. And a high fraction GOT BETTER. Why, then, do we have to wait a decade or so for tests to show that it helps everyone? If your buddy want to try this (it's an autogenous vaccine), why can't he bloody do it?

Lawyers and Bureaucrats.

I just heard on Fox news that in won't be able to the public for at least 3 years.

[Gabz]

I just heard the same thing on FNC

Lawyers and Bureaucrats.

And add the antis and the charity and body parts cartel.........a vaccine against lung cancer will cause them to lose much of their funding to continue denormalizing smokers.

[solzhenitsyn]

Oh definitely, Smoking prevents Alzheimer's and Parkinson's disease ...

If that's true, I suspect it's a by-product of smoking preventing old age.

[HuntsvilleTxVeteran]

Smoke smoke smoke that cigarette puff puff puff and if you smoke yourself to death

[qam1]

If that's true, I suspect it's a by-product of smoking preventing old age.

The effect and pathway with regards to nicotine preventing and treating Alzheimer's is well known,

Here knock yourself out

[qam1]

Here knock yourself out

OK that didn't work, Try

Glycation of the amyloid beta-protein by a nicotine metabolite: a fortuitous chemical dynamic between smoking and Alzheimer's disease.

Nicotinic treatment for cognitive dysfunction.

[TwoBear]

95% of all lung cancers are caused by smoking. No smoking, no lung cancers.

[Rainmist]

But what kind of lung cancer did it work on ?