What will deGrasse Tyson do when he discovers who is running the simulation? ;-) If he means all of creation is held in the mind of God, and without Him we are nothing, I might go along with him a bit.
But whatever the cause of the simulation is....it would mean our “science” is an illusion.. but then didn’t Tyson come to his conclusion based on what our “scientific” knowledge has inferred? Conundrum city.