Maria was born on April 27, 1878 in Zapopan, Jalisco, Mexico. Her father, Fortino, ran a religious goods store situated in front of the Basilica of Our Lady of Zapopan. She had a special devotion to the Lady and she made frequent prayers in the basilica.
As a young woman, she made plans to marry, however she ended these plans as she felt called to religious life.
She then pursued religious life and co-founded a new congregation on October 13, 1901, known as the Handmaids of St. Margret Mary Alacoque and the Poor. Maria spent most of her time serving as a nurse and as the Mother Superior General of the congregation.
The Congregation grew rapidly and served ever more people. However, she was also devoted to poverty, saying that only by being poor can one be with the poor. She sometimes begged for money on the street to help meet the needs of the Congregation and the patients they served.