Ping!
Going back to Henry VIII and his break with Rome, is the basis for the English and American anti-Catholicism. Remember that Queen Mary brought back Catholicism and ordered the execution of her father’s supporters of the break with Rome. As Henry had done with those who refused to break with Rome. It was also a world where Rome had political influence and was allied with Spain, France and the Holy Roman Empire.
In America, the English colonists saw the Spanish and French as enemies, both political and religious.
But one needs also to remember that in Maryland was a colony established for English Catholics. And it succeeded as a colony and also sought independence from England.
And in the late 1800s and early 20th Century, the immigrants from Catholic areas of Europe, also was seen as bringing socialism with it. Thus a new political issue was mixed into the old religious fears.
The key point is that many have striven to overcome these old hates as something that deserves to be in the past and NOT be used as reasons to keep them alive today.