Singapore Temporarily Halts Use of Two Flu Vaccines After South Korea Deaths

Singapore has temporarily halted the use of two influenza vaccines as a precaution after some people who received them in South Korea died, becoming among the first countries to publicly announce a halt of the vaccines' usage.

South Korea reported that 48 have died as of Saturday after getting flu shots, but said it would carry on with the state-run vaccination programme as they found no direct link between the deaths and the shots.

No deaths associated with influenza vaccination have been reported in Singapore to date, but the decision to halt the use of SKYCellflu Quadrivalent and VaxigripTetra was precautionary, the health ministry and the Health Sciences Authority (HAS) said in a statement late on Sunday.

The HSA is in touch with the South Korean authorities for further information as they investigate to determine if the deaths are related to influenza vaccinations.

SKYCellflu Quadrivalent is manufactured by South Korea's SK Bioscience and locally distributed by AJ Biologics, while VaxigripTetra is manufactured by Sanofi and locally distributed by Sanofi Aventis.

Two other influenza vaccines that have been brought into Singapore for the Northern Hemisphere 2020/21 influenza season may continue to be used, Singapore health authorities said.

The link below is positively the best summary of Dr. Zelenko’s work and that of many, many others. They feel the use of virus killer ZINC with relatively safe ionophores like HCQ, Quercetin; Ivermectin, and others, with the possible addition of an antibiotic like Azithromycin or one of several others is the way to reopen the economy and schools relatively safely. The point is, stop stalling for development of high priced items like Remdesivir and vaccines. Start making low cost treatments and outpatient treatment models recognized immediately. The key is 1) some virus killer (like zinc or Kaletra), 2)some ionophore that helps the killer enter infected cells, and 3) some lung protector like an antibiotic to kill bacteria or even a vitamin like Vitamin C that strengthens cell walls, or D3 which may prevent the deironization of red blood cells. Please send this link far and wide after you check it out yourself.

https://faculty.utrgv.edu/eleftherios.gkioulekas/zelenko/index.html

It is at least 7 printed pages of links and information. Near the end, a number of you-tube (Google) sites which have been censored (removed) are listed to be reached elsewhere.

Regarding possible dangers of flu vaccine: Vaccines cause immediate depletion of various vitamins and minerals like Vitamin C, D3, and zinc. An early link at the above site makes recommendations of supplements to strengthen immunity. I will take extra supplements (in addition to the ones I normally take) for a few days before and after getting the flu vaccine. That should protect one from becoming more vulnerable to Covid. Remember, if your taste and smell suddenly goes, your body’s zinc is probably severely depleted. Dr. Z recommends 220 mg of Zinc Sulfate (50 mg. of elemental zinc). You may need to do the calculation for elemental zinc in items like zinc picolinate or others. Good luck, happy hunting, be well.

Thank you for posting this link. Here is a portion of the article on the first portion of the page, for those uncertain regarding clicking on unknown links:

- - - - - - - - - - - - - - - - - - - - - - - - - -
THE LINKS ARE ON THE PAGE REFERRED TO BY gleeaikin, given above. Please go there for the links. Alternatively, I have listed the original letter from Dr. Zelenko in a following post.

- - - - - - - - - - - - - - - - - - - - - - - - - -

“If you are in a hurry

Given the extensive amount of information of this website, a quick way to get started is as follows:

Read the treatment protocol and prophylaxis protocol documents by Dr. Zelenko.
Read Dr. Paul Marik’s documents on the MATH+ protocol
Watch the interviews of Dr. Zelenko, Dr. Risch, and Dr. Marik.
Read the papers by Dr. Zelenko, Dr. Risch, Dr. McCullough, and Dr. Marik.

For early outpatient care: Read this article by Dr. Vliet, and try the telemd program organized by Dr. Jerome Corsi or the telemd program by Dr. Stella Immanuel.
Introduction

This webpage curates content related to the early outpatient treatment protocol that has been proposed by Dr. Vladimir Zelenko for the SARS-CoV-2 virus. Dr. Zelenko originally risk-stratified patients and treated high-risk patients with hydroxychloroquine, zinc, and azithromycin. He has since evolved his protocols to include a quercetin protocol for low-risk patients as well as guidelines for prophylaxis. Dr. Zelenko shared the details of his protocol on March and April 2020 in open letters to the medical community and also shared updated treatment and prophylaxis protocols on August 2020. He has also published his first research paper on his treatment protocol. See the press release. Dr. Zelenko’s paper establishes, with statistical significance, that his early outpatient protocol reduces hospitalizations by 84%. This is a conservative estimate of the protocol’s potential because most patients were treated on Day 4-6, and because the control group included an unknown number of low-risk patients. We should expect better results if treatment is initiated on Day 1.

The website c19study.com is tracking research studies of hydroxychloroquine. This website has been created by the anonymous CovidAnalysis group (they are anonymous to avoid personal threats and cancel culture). They have also put together two interestimg dynamic meta-studies: here and here. These studies are dynamically updated via software as new data is becoming available.

A recent white paper by Dr. Simone Gold (founder of American Frontline Doctors) has documented the safety profile of hydroxychloroquine. Dr. Harvey Risch, from the Yale School of Public Health (and more importantly, a Caltech alumnus from Fleming House), has also published a peer reviewed paper documenting that the aggregate of all research studies to date support the efficacy of the Zelenko protocol, when administered at the early stages of the disease. In doing so, he was criticized by Yale colleagues and wrote a very strong response explaining the fundamentals of the mechanism by which some studies have been used to confound, mislead, and manipulate.

The Eastern Virginia Medical School maintains an interesting website with current information for medical practitioners. They recommend an interesting MATH+ treatment protocol for hospitalized patients. They also recommend a quercetin protocol both for prophylaxis and at-home treatment for all patients, but do not recommend hydroxychloroquine protocol, as of June 2020. Both quercetin and hydroxychloroquine are zinc ionophores, however hydroxychloroquine has additional mechanisms of action. Note that Dr. Zelenko recommends that the hydroxychloroquine protocol should be prescribed only to at-risk patients, identified as such via specific risk stratification criteria, . . .

and recommends the quercetin protocol for low-risk patients.”

May 11, 2015 12:00 am
Hydroxychloroquine is one of many medications frequently used in rheumatology practice. Its remarkable versatility is attested by its routine use in lupus, in patients with an autoimmune coagulopathy, in patients with rheumatoid arthritis, as well as those with a low-level inflammatory arthropathy. It’s an amazing medication, with a novel history and wide array of indication and multiple actions that we now better understand.

The HCQ story begins in 1638 when the wife of the Viceroy of Peru, Countess Cinchona, acquired malaria while living in the New World. Rather than getting the “approved” therapy, blood-letting, she was treated by an Incan herbalist with the bark of a tree (eventually, named for the countess-Cinchona Tree). Her response was dramatic; when the Viceroy returned to Spain, he brought with him large supplies of the powder for general use, which at the time was controlled by the Church and was thus called “Jesuit’s Powder”.
It took nearly two centuries for the active substance, Quinine, to be isolated from the bark (and was eventually to make a name for itself as a tonic to be added to gin).
Over the next century, quinine would become a common component in folk medicines and patent remedies for the treatment of malaria in the southern states of America, as well as for generic malaise. By the 1940s, quinine, or rather its derivative chloroquine, was recognized for its anti-malarial properties and found use among troops fighting in the Pacific during WW-II. However, it was noted that this compound had significant toxicities. In 1945, a modification of this compound via hydroxylation led to the development of HCQ, which was found to be less toxic and remains in use, without change, to this day.
Over time, physicians began to experiment with the medication and, in the early 1950s, began to use it for the treatment of SLE. After the success in that disease (at least success relative to the other available agents which were basically none), it was tried in another arthropathy, RA. However, in the quest to get better responses, physicians would “push” the dose and, not surprisingly, toxicities, most notable retinal toxicity, began to present itself as a limiting feature of the medication. Not deterred, physicians adjusted the dose and began to consider using it in combination therapy, which became popular in the 1980s and has culminated in the recent studies showing the notable efficacy of triple therapy when HCQ was combined with MTX and sulfasalazine.
Most of the science regarding HCQ’s mechanism of action falls in the realm of speculation. There is evidence that one of its primary effects is on the lysosome, where it accumulates. Once there, it can stabilize the lysosomal membrane and elevate the intra-organelle pH, leading to inactive acid proteases, decreased receptor recycling, inhibition of protein/cytokine production and secretion, and interference with intracellular inflammatory pathways such as ERK and MAP kinase. Recently, there is some evidence that it also inhibits certain segments of “innate immunity” (that basic immunity which links us to jellyfish), specifically the toll-like receptors. Through its action on TLR3/4, synovial fibroblasts are less likely to become activated. Its effect on TLR7/9 inhibits TNF production.
I’m a clinician, not a molecular biologist, and what I want to know is: does it work and where or when?
The most impressive work has come from the lupus literature. This underappreciated medication has been clearly shown to reduce the number of SLE flares, reduce the severity of SLE flares when they occur, can in some cases lead to “remission” including lupus nephritis, increase the risk of flares when stopped, and decrease the doses of prednisone needed to control the disease. In at least one study, the use of HCQ increased survival in patients with SLE by 70%.
Of equal importance, HCQ has been shown to decrease the risk of thrombosis in patients who are anti-phospholipid antibody positive. Although no studies have been done to specifically look at it during pregnancy, most feel it is safe to continue through pregnancy in patients with SLE, despite its long T1/2 of 40 hours and its ability to cross the placenta with ease. In a study of 133 pregnancies in patients on HCQ there were no differences in fetal outcome compared to 70 pregnancies seen in a control group. One has to weigh the potential unknown risks of HCQ against the known risk of pregnancy outcome in SLE patients who flare.
HCQ has also been a pivotal drug in RA. While it demonstrated some efficacy in RA as monotherapy, HCQ has really made its name is in combination therapy. The first major publication to look at a combination therapy tested MTX+HCQ, MTX+HCQ+SSZ and MTX+SSZ in patients with established RA. While “triple” did the best, MTX+SSZ did worse than either combination using HCQ. There may be an explanation for this, coming from the Oncology literature. MTX needs to be actively transported into the cells to become polyglutamated, which is the active form of MTX. It turns out that SSZ inhibits this transport system, and this inhibition is counteracted by HCQ. Makes you think twice about using MTX+SSZ without HCQ, doesn’t it?
But wait, there’s more…
It appears that in patients with RA who are treated with HCQ, there is a decreased likelihood of developing diabetes compared to those who never took it. Even more impressive, RA patients taking HCQ for more than 36 consecutive months were 70% less likely to have an incident cardiovascular event than those not taking it. Regrettably, HCQ is not the cure for all diseases. In one condition in which you would have expected to see an effect, Sjogren’s syndrome, the recent studies have been disappointing.
Now, before we starting putting HCQ in the water supply, we have to recognize that it has its toxicities. The best known is the retinal damage, which can lead to blindness. The risk increases by >1% for each year that the patient is on the medication. Monitoring with eye exams will usually control for this. Myopathies and cardiomyopathies have been described; on biopsy there is a characteristic vacuolar degeneration noted on muscle biopsy. Neuropathies, including ototoxcitiy (it’s not just the eyes…) have been reported, and in rare occasions, there can be a pigmentation of the cartilage presenting like ochronosis. All in all, it’s a pretty safe drug, especially if doses are kept below 6.5mg/kg.
HCQ has come a long way from the Incas making powder from the bark of the Cinchona tree, to having the ACR and EULAR endorse the use of HCQ in the treatment of RA and SLE. The next time you prescribe HCQ, keep in mind the enduring power of this time-tested - nearly four centuries - amazing medicine.
REFERENCES
Ann Rheum Dis 2010; 69.20-28
Ann Rheum Dis 2007; 66.1168-1172
Arthritis Rheum 2002; 46(5). 1164-1170
Arthritis Care & Res 2010; 62(2). 775-784

Disclosures
The author has no conflicts of interest to disclose related to this subject

Martin J. Bergman, MD
(4 Posts)
Dr. Bergman is Clinical Associate Professor of Medicine at Drexel University College of Medicine in Philadelphia and is Chief of the Section of Rheumatology at Taylor Hospital in Ridley Park, PA. He has been in private practice for over 25 years and has published extensively on the use of disease measurement tools in the treatment of rheumatic diseases. As an active national and international lecturer, he has had the opportunity to present lectures on topics ranging from the history of drug development and treatment modalities in rheumatic diseases, to how to interpret statistical data.

SUCCESSFUL THERAPY AGAINST COVID-19 VIRUS from New York State:
Dr. Vladimir (Zev) Zelenko
Board Certified Family Practitioner
501 Rt 208, Monroe, NY 10950
845-238-0000
March 23, 2020
To all medical professionals around the world:
My name is Dr. Zev Zelenko and I practice medicine in Monroe, NY. For the last 16 years, I have cared for approximately 75% of the adult population of Kiryas Joel, which is a very close knit community of approximately 35,000 people in which the infection spread rapidly and unchecked prior to the imposition of social distancing.
As of today my team has tested approximately 200 people from this community for Covid-19, and 65% of the results have been positive. If extrapolated to the entire community, that means more than 20,000 people are infected at the present time. Of this group, I estimate that there are 1500 patients who are in the high-risk category (i.e. >60, immunocompromised, comorbidities, etc).
Given the urgency of the situation, I developed the following treatment protocol in the pre-hospital setting and have seen only positive results:
1. Any patient with shortness of breath regardless of age is treated.
2. Any patient in the high-risk category even with just mild symptoms is treated.
3. Young, healthy and low risk patients even with symptoms are not treated (unless their circumstances change and they fall into category 1 or 2).
My out-patient treatment regimen is as follows:
1. Hydroxychloroquine 200mg twice a day for 5 days
2. Azithromycin 500mg once a day for 5 days
3. Zinc sulfate 220mg once a day for 5 days
The rationale for my treatment plan is as follows. I combined the data available from China and South Korea with the recent study published from France (sites available on request). We know that hydroxychloroquine helps Zinc enter the cell. We know that Zinc slows viral replication within the cell. Regarding the use of azithromycin, I postulate it prevents secondary bacterial infections. These three drugs are well known and usually well tolerated, hence the risk to the patient is low.
Since last Thursday, my team has treated approximately 350 patients in Kiryas Joel and another 150 patients in other areas of New York with the above regimen.
Of this group and the information provided to me by affiliated medical teams, we have had ZERO deaths, ZERO hospitalizations, and ZERO intubations. In addition, I have not heard of any negative side effects other than approximately 10% of patients with temporary nausea and diarrhea.
In sum, my urgent recommendation is to initiate treatment in the outpatient setting as soon as possible in accordance with the above. Based on my direct experience, it prevents acute respiratory distress syndrome (ARDS), prevents the need for hospitalization and saves lives.
With much respect,
Dr. Zev Zelenko
cc: President Donald J. Trump; Mr. Mark Meadows, Chief of Staff
Video at Link
https://matzav.com/watch-kiryas-yoel-dr-zev-zelenko-to-trump-im-seeing-success-with-your-approved-drug/?fbclid=IwAR0gVHAW9kWF-JLRHjzQx9bSFx6jlRgTn9_PpAmaiykXhsVqTE7wJrddS4g

8 posted on 3/24/2020, 5:02:30 PM by Candor7 ((Obama Fascism)http://www.americanthinker.com/articles/2009/05/barack_obam_the_quintessentia_1.html))
[ Post Reply | Private Reply | To 1 | View Replies]
= = = = = = = = = = = = = = = = = = = = = = = = = = = =

EDITORIAL, not a medical professional:
Most likely, we are all going to get this, or have a loved one who does, or we’ve already had it.

Because the Hydroxychloroquine (quinine derivative) is such an old, well-known and tolerated drug, (used world-wide for malaria without prescription for over 70 years) and is generic, which means it is quite cheap and will not make huge profits, it is being denigrated and withheld as much as possible.

Try to get your doctor to prescribe it, and then a pharmacy to fill it.
It is commonly prescribed long-term for autoimmune diseases such as rheumatiod arthritis and lupus.

For those of us who can’t get this Hydroxychloroquine (HCQ) for whatever reason, there are substitutes. So keep this information, look it up, try it out when you or your loved one gets sick. .

Here are some substitutes:

1. Hydroxychloroquine (HCQ) (Quinine derivative) 200mg twice a day for 5 days
SCHWEPPS Tonic Water contains 80mg per liter of QUININE. 3 liters of the stuff will have about 240mg of Quinine. 5 liters will give you the same daily amount as above (200mg twice day = 400mg)
They tell you to push fluids when sick. So, SCHWEPPS Tonic water. Try the 3 liters. Get zinc in cells.

2. Azithromycin (Zpak) 500mg once a day for 5 days
Can’t get Zpak? If you take enough vitamin C (10-20 grams per day, spaced out about a gram (1000 mg ) per hour, it acts like an antibiotic. Maybe dissolve in the tonic, but don’t take pills on an empty stomach. If your stool gets soft, skip three hours and dial it back to a gram every other hour. (But you will absorb more vitamin c than you ever thought you could.)

3. Zinc sulfate 220mg once a day for 5 days. (THE ZINC IS THE ANTIVIRAL AGENT)
Zinc piccolinate, zinc glycinate, zinc gluconate supplements, all seem to work just fine. Check locally, order Amazon, or Puritans Pride www.puritan.com stock #2000 will work, or LifeExtension Foundation#01561 or #01961 www.lef.org. Advise the zinc 220mg dose for 5 days, then back to RDA of 22-25mg daily..

While surfing the many sources in my link at Comment #9, I got lost in a 37 page item from Eastern Virginia Medical School (EVMS)in Norfolk. See link below. I hope our naval forces in Norfolk are benefiting from their wisdom since it seems fairly good. They do actually mention zinc, and while they are wary of HCQ, the do have a high opinion of Ivermectin as an ionophore, and also recommend Quercetin. [Personally, I would like to see a study comparing HCQ, Ivermectin, or Quercetin as ionophores used with an antiviral like zinc or Kaletra as the antiviral, and vitamin C plus an appropriate medicine/antibiotic for lung protection—six combinations in all with these ionophore and antiviral choices.] On page 4 is an important diagram that shows where the early antiviral treatment phase, so emphasized by Dr. Zelenko’s 3 part protocol, passes into the Pulmonary Phase which seems to require other treatments. These can include Vitamin C and Anti-inflammatory Rx. Here is the link. https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf

Continuing: Pages 6-10 have detailed dose and medication information including a shout-out to Vitamin D. Treatments include, Prophylaxis, At Home, Mildly Symptomatic in Hospital; ICU Essential Treatment (good Vit. C details), 22 Additional Treatments, including Salvage Treatment. Pages 19-21 provide Key Concepts of the EVMS Treatment Protocol(s). Page 23-24 give Scientific Rational for MATH+* Treatment Protocol (pulmonary phase). Pages I have not mentioned have charts and graphs, some of which I do not understand. Finally, a number of pages have over 300 References, mostly scientific papers.

I have not yet researched the 50 mg. Elemental Zinc question; however, a one daily type supplement and a cal/mag/zinc supplement list 100% RDA for zinc as ranging between 11 mg. and 15 mg. Thus you would look for the RDA% listed on a zinc supplement and take around 400% to 500% of RDA. With the one-daily or cal/mag/zn using 4 times the listed dose that would give 44 mg. or 60 mg. elemental zinc. EVMS recommends higher doses for symptomatic patients at home and in the hospital.

* EVMS’s MATH+ protocol for severely ill is described on page 1 of this link.

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.