Posted on 05/02/2020 5:07:47 PM PDT by Hojczyk
The Wuhan epidemic has exposed a rift between the academic medicine types who dominate the Centers for Disease Control and similar agencies in the states and practicing physicians who are actually treating COVID patients. The former have generally been unhelpful; CDC in particular has performed poorly. Meanwhile, doctors on the front line have developed effective treatment regimens for the virus–regimens which apparently would save many lives if they were broadly publicized and implemented.
[I]t is the severe inflammation sparked by the Coronavirus, not the virus itself, that kills patients. Inflammation causes a new variety of Acute Respiratory Distress Syndrome (ARDS), which damages the lungs.
Practicing doctors are highly familiar with inflammatory conditions and a number of known treatments have been adapted to COVID-19. The linked bulletin advocates early intervention–the key–using Vitamin C, heparin, Methylprednisolone and Hydroxychloroquine.
It seems to be increasingly clear that both the World Health Organization and the Centers for Disease Control have been worse than useless in the present epidemic. Happily, front-line doctors are learning from experience what treatments can be helpful. As they continue to share information, it is reasonable to expect that fatalities associated with the Wuhan virus will decline. A consensus as to effective treatment is likely to reached long before a vaccine is available.
(Excerpt) Read more at powerlineblog.com ...
My understanding is that it is primarily the reduced oxygen carrying capacity of the blood that kills, hence the very high danger to the obese.
Bump!
The doctors on the front lines have also gotten good results with oxygenation and proning. These have largely replaced the use of ventilators, except in the very worst cases.
A lot of medical stuff at the site
https://www.powerlineblog.com/archives/2020/05/how-treatable-is-covid-19.php
The CDC is full of IYI doctors....doctors who know less than an EMT about treatment of real people.....
My kid at sixteen got his ski patrol certification....there was a doctor who failed....did not have the ability to treat people on the ski slope...
It’s like Pentagon generals trying to run a war and not listening to the guys in the field,
How long was it in 1941 before the experts and government/military leader referred to the
"Japanese attack on Pearl Harbor", instead of only using the names of the types of aircraft used?
According to this link it’s very treatable.
VERY treatable. If it wasn’t, China would no longer exist. It would’ve ravaged their country by now.
Don’t know how treatable, but it is very easily preventable based on my activities at age 80.
Was on a crowded cruise ending on Feb 29th, 2020.
Been to grocery stores at least once a week since the cruise ended. But I leave if I hear any one coughing nearby in store.
Been to bank and pick up restaurant food many times.
Accompanied wife every 3 weeks for her chemo treatment to sit in with the doctor.
Filled in gas a few times touching the dirtiest place touched by many others...the gas pump dispenser.
Only thing we have been doing is wash hands before touching face. Wearing mask mainly helps others getting infected by you.
That looks good. It's from the Eastern Virginia Medical School.
It’s like Pentagon generals trying to run a war and not listening to the guys in the field,
—
That never happens. Wait, that happens all the time, and for much the same reasons. The higher ups in government have a political agenda that involves connected contractors or companies who funnel money to their bought and paid for politicians for their pet projects. The actual needs of the soldiers be damned.
I am not being smart alec by asking this but am serious. So lets say someone was near you and they had the virus and they coughed by you if you had good hygiene washing your hands and such would you not catch the virus even if you were an older person?
How the CORONAVIRUS does its dirty work.
Covid-19 had us all fooled, but now we might have finally found its secret
medium ^ | 5 April 2020 | libertymavenstock
Posted on 4/7/2020, 1:33:16 PM by COBOL2Java
In the last 3–5 days, a mountain of anecdotal evidence has come out of NYC, Italy, Spain, etc. about COVID-19 and characteristics of patients who get seriously ill. It’s not only piling up but now leading to a general field-level consensus backed up by a few previously little-known studies that we’ve had it all wrong the whole time. Well, a few had some things eerily correct (cough Trump cough), especially with Hydroxychloroquine with Azithromicin, but we’ll get to that in a minute.
There is no ‘pneumonia’ nor ARDS. At least not the ARDS with established treatment protocols and procedures we’re familiar with. Ventilators are not only the wrong solution, but high pressure intubation can actually wind up causing more damage than without, not to mention complications from tracheal scarring and ulcers given the duration of intubation often required… They may still have a use in the immediate future for patients too far to bring back with this newfound knowledge, but moving forward a new treatment protocol needs to be established so we stop treating patients for the wrong disease.
The past 48 hours or so have seen a huge revelation: COVID-19 causes prolonged and progressive hypoxia (starving your body of oxygen) by binding to the heme groups in hemoglobin in your red blood cells. People are simply desaturating (losing o2 in their blood), and that’s what eventually leads to organ failures that kill them, not any form of ARDS or pneumonia. All the damage to the lungs you see in CT scans are from the release of oxidative iron from the hemes, this overwhelms the natural defenses against pulmonary oxidative stress and causes that nice, always-bilateral ground glass opacity in the lungs. Patients returning for re-hospitalization days or weeks after recovery suffering from apparent delayed post-hypoxic leukoencephalopathy strengthen the notion COVID-19 patients are suffering from hypoxia despite no signs of respiratory ‘tire out’ or fatigue.
Here’s the breakdown of the whole process, including some ELI5-level cliff notes. Much has been simplified just to keep it digestible and layman-friendly.
Your red blood cells carry oxygen from your lungs to all your organs and the rest of your body. Red blood cells can do this thanks to hemoglobin, which is a protein consisting of four “hemes”. Hemes have a special kind of iron ion, which is normally quite toxic in its free form, locked away in its center with a porphyrin acting as it’s ‘container’. In this way, the iron ion can be ‘caged’ and carried around safely by the hemoglobin, but used to bind to oxygen when it gets to your lungs.
When the red blood cell gets to the alveoli, or the little sacs in your lungs where all the gas exchange happens, that special little iron ion can flip between FE2+ and FE3+ states with electron exchange and bond to some oxygen, then it goes off on its little merry way to deliver o2 elsewhere.
Here’s where COVID-19 comes in. Its glycoproteins bond to the heme, and in doing so that special and toxic oxidative iron ion is “disassociated” (released). It’s basically let out of the cage and now freely roaming around on its own. This is bad for two reasons: Glycoproteins and lipids
Glycoproteins are found on the surface of the lipid bilayer of cell membranes. Their hydrophilic nature allows them to function in the aqueous environment, where they act in cell-cell recognition and binding of other molecules. The CORONAVIRUS has such a cover and BHT (if you like it or not) will remove this cover and as such prevent the virus from attaching itself.
1) Without the iron ion, hemoglobin can no longer bind to oxygen. Once all the hemoglobin is impaired, the red blood cell is essentially turned into a Freightliner truck cab with no trailer and no ability to store its cargo.. it is useless and just running around with COVID-19 virus attached to its porphyrin. All these useless trucks running around not delivering oxygen is what starts to lead to desaturation, or watching the patient’s spo2 levels drop. It is INCORRECT to assume traditional ARDS and in doing so, you’re treating the WRONG DISEASE. Think of it a lot like carbon monoxide poisoning, in which CO is bound to the hemoglobin, making it unable to carry oxygen. In those cases, ventilators aren’t treating the root cause; the patient’s lungs aren’t ‘tiring out’, they’re pumping just fine. The red blood cells just can’t carry o2, end of story. Only in this case, unlike CO poisoning in which eventually the CO can break off, the affected hemoglobin is permanently stripped of its ability to carry o2 because it has lost its iron ion. The body compensates for this lack of o2 carrying capacity and deliveries by having your kidneys release hormones like erythropoietin, which tell your bone marrow factories to ramp up production on new red blood cells with freshly made and fully functioning hemoglobin.
This is the reason you find elevated hemoglobin and decreased blood oxygen saturation as one of the 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.
2) That little iron ion, along with millions of its friends released from other hemes, are now floating through your blood freely. As I mentioned before, this type of iron ion is highly reactive and causes oxidative damage. It turns out that this happens to a limited extent naturally in our bodies and we have cleanup & defense mechanisms to keep the balance. The lungs, in particular, have 3 primary defenses to maintain “iron homeostasis”, 2 of which are in the alveoli, those little sacs in your lungs we talked about earlier. The first of the two are little macrophages that roam around and scavenge up any free radicals like this oxidative iron. The second is a lining on the walls (called the epithelial surface) which has a thin layer of fluid packed with high levels of antioxidant molecules.. things like abscorbic acid (AKA Vitamin C) among others. Well, this is usually good enough for naturally occurring rogue iron ions but with COVID-19 running rampant your body is now basically like a progressive state letting out all the prisoners out of the prisons… it’s just too much iron and it begins to overwhelm your lungs’ countermeasures, and thus begins the process of pulmonary oxidative stress.
This leads to damage and inflammation, which leads to all that nasty stuff and damage you see in CT scans of COVID-19 patient lungs. Ever noticed how it’s always bilateral? (both lungs at the same time) Pneumonia rarely ever does that, but COVID-19 does… EVERY. SINGLE. TIME.
Once your body is now running out of control, with all your oxygen trucks running around without any freight, and tons of this toxic form of iron floating around in your bloodstream, other defenses kick in. While your lungs are busy with all this oxidative stress they can’t handle, and your organs are being starved of o2 without their constant stream of deliveries from red blood cell’s hemoglobin, and your liver is attempting to do its best to remove the iron and store it in its ‘iron vault’. Only its getting overwhelmed too. It’s starved for oxygen and fighting a losing battle from all your hemoglobin letting its iron free, and starts crying out “help, I’m taking damage!” by releasing an enzyme called alanine aminotransferase (ALT). BOOM, there is your second of 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.
Eventually, if the patient’s immune system doesn’t fight off the virus in time before their blood oxygen saturation drops too low, ventilator or no ventilator, organs start shutting down. No fuel, no work. The only way to even try to keep them going is max oxygen, even a hyperbaric chamber if one is available on 100% oxygen at multiple atmospheres of pressure, just to give what’s left of their functioning hemoglobin a chance to carry enough o2 to the organs and keep them alive. Yeah we don’t have nearly enough of those chambers, so some fresh red blood cells with normal hemoglobin in the form of a transfusion will have to do.
The core point being, treating patients with the iron ions stripped from their hemoglobin (rendering it abnormally nonfunctional) with ventilator intubation is futile, unless you’re just hoping the patient’s immune system will work its magic in time. The root of the illness needs to be addressed.
Best case scenario? Treatment regimen early, before symptoms progress too far. Hydroxychloroquine (more on that in a minute, I promise) with Azithromicin has shown fantastic, albeit critics keep mentioning ‘anecdotal’ to describe the mountain, promise and I’ll explain why it does so well next. But forget straight-up plasma with antibodies, that might work early but if the patient is too far gone they’ll need more. They’ll need all the blood: antibodies and red blood cells. No help in sending over a detachment of ammunition to a soldier already unconscious and bleeding out on the battlefield, you need to send that ammo along with some hemoglobin-stimulant-magic so that he can wake up and fire those shots at the enemy.
The story with Hydroxychloroquine
All that hilariously misguided and counterproductive criticism the media piled on chloroquine (purely for political reasons) as a viable treatment will now go down as the biggest Fake News blunder to rule them all. The media actively engaged their activism to fight ‘bad orange man’ at the cost of thousands of lives. Shame on them.
How does chloroquine work? Same way as it does for malaria. You see, malaria is this little parasite that enters the red blood cells and starts eating hemoglobin as its food source. The reason chloroquine works for malaria is the same reason it works for COVID-19 — while not fully understood, it is suspected to bind to DNA and interfere with the ability to work magic on hemoglobin. The same mechanism that stops malaria from getting its hands on hemoglobin and gobbling it up seems to do the same to COVID-19 (essentially little snippets of DNA in an envelope) from binding to it. On top of that, Hydroxychloroquine (an advanced descendant of regular old chloroquine) lowers the pH which can interfere with the replication of the virus. Again, while the full details are not known, the entire premise of this potentially ‘game changing’ treatment is to prevent hemoglobin from being interfered with, whether due to malaria or COVID-19.
No longer can the media and armchair pseudo-physicians sit in their little ivory towers, proclaiming “DUR so stoopid, malaria is bacteria, COVID-19 is virus, anti-bacteria drug no work on virus!”. They never got the memo that a drug doesn’t need to directly act on the pathogen to be effective. Sometimes it’s enough just to stop it from doing what it does to hemoglobin, regardless of the means it uses to do so.
Anyway, enough of the rant. What’s the end result here? First, the ventilator emergency needs to be re-examined. If you’re putting a patient on a ventilator because they’re going into a coma and need mechanical breathing to stay alive, okay we get it. Give ’em time for their immune systems to pull through. But if they’re conscious, alert, compliant — keep them on O2. Max it if you have to. If you HAVE to inevitably ventilate, do it at low pressure but max O2. Don’t tear up their lungs with max PEEP, you’re doing more harm to the patient because you’re treating the wrong disease.
Ideally, some form of treatment needs to happen to:
1. Inhibit viral growth and replication. Here plays CHQ+ZPAK+ZINC or other retroviral therapies being studies. Less virus, less hemoglobin losing its iron, less severity and damage.
2. Therapies used for anyone with abnormal hemoglobin or malfunctioning red blood cells. Blood transfusions. Whatever, I don’t know the full breadth and scope because I’m not a physician. But think along those lines, and treat the real disease. If you’re thinking about giving them plasma with antibodies, maybe if they’re already in bad shape think again and give them BLOOD with antibodies, or at least blood followed by plasma with antibodies.
3. Now that we know more about how this virus works and affects our bodies, a whole range of options should open up.
4. Don’t trust China. China is ASSHOE. (disclaimer: not talking about the people, just talking about the regime). They covered this up and h
One of the best kept secrets around is BHT short for butylated hydroxy toluene.
It has been around for the better part of thirty years or more, has been approved as a food additive by the FDA as safe for human consumption in small quantities and using common sense. Without going into all the details which would fill many pages some of the benefits are difficult to ignore even so pharmaceutical as well as the medical profession does their best to do so. As a prophylactic it would serve its purpose very well until the right vaccine comes along, without any undesirable side effects, besides being inexpensive and is safer than alcohol consumption, use of tobacco or many other unhealthy eating habits.
Some of the reasons are that that there is no money to be made by pharmaceutical companies as patents related to BHT ran out long time ago and in order to have it approved for medical application it would require an immeasurable amounts of human tests with expenditures in the millions of Dollars which most likely will never be recovered.
On the other hand many doctors may know about it but will refrain from suggesting it as recommending anything which is not approved by the FDA would leave them wide open to lawsuits, as it is pretty well known that one of the American dreams is, to fall on your neighbors property and then sue them for what ever they can get.
Over the years enough information about BHT has surfaced that if used in small quantities to achieve a particular result, such as from 100 mg to about 1g (one gram or 1000mg) and in most cases 250mg to 450mg may do a nice job for some of the things suggested, it may be less harmful than an equivalent amount of Aspirins. Again do your own research and use common sense which appears to be in short supply these days.
Even so, if you still apprehensive or hesitant use it only when one of those nasty viruses appears on the scene and use it as a prophylactic in a small quantity perhaps 200 mg and once the danger subside stop taking it. The catch is that in order to do its job BHT works better before you get sick, as BHT will NOT REPAIR ANY DAMAGE which may already have been done by an infectious disease such as the corona virus. Even so if taken afterwards BHT will still continue to disable lipid covered viruses, but to repair any damage already caused may require different medications.
So why to take BHT on the firs place? It has been long known that BHT will remove the lipid layer or cover from LIPID COVERED viruses and the coronavirus happens to be just such a virus and by doing so will prevent such a virus from attaching itself and do its dirty work.
The Principal Benefits of BHT
In order of importance, supplementing with BHT can help with:
Reduce and prevent viral infections such as herpes, thus terminating their outbreaks. Also BHT is effective against many different human and animal viruses including CMV (cytomegalovirus),9 pseudorabies,10 genital herpes,11HIV,12 and some strains of influenza.13 A few of the viruses that have a lipid envelope and may be treated by BHT include herpes simplex I, herpes simplex II, herpes zoster, CMV, West Nile virus, HIV virus, influenza virus, hepatitis B and C viruses, avian flu influenza virus and the SARS virus. However, BHT has not been clinically tested to treat these infections.
The CORONAVIRUS is also a lipid covered virus and BHT affects the lipid covering and in turn prevents the virus from attaching itself and do its damage. Now keep in mind that very few things in life are perfect and this holds true for vaccines as well. So when everything comes down to being cut and dried, do you prefer risking being infected with a nasty virus with all kinds of unpredictable side effects or take a chance with some substance which overall has a very good safety record.
Besides most viruses will mutate over time, and by the time someone may come up with the proper vaccine it may no longer match the virus which is currently making its round. But BHT doesn’t care if such a virus mutates or not. As long as such a virus has a lipid coating it will remove it and disable such a virus.
COVID-19 TREATMENT PROTOCOL
In all COVID-19 hospitalized patients, the therapeutic focus must be placed on early intervention utilizing powerful, evidence-based therapies to counteract:
•the overwhelming and damaging inflammatory response
•the systemic and severe hyper-coagulable state causing organ damage
By initiating the protocol within 6 hours of presentation in the emergency room, the need for mechanical ventilators and ICU beds will decrease dramatically.
THERAPEUTIC PROTOCOL TO CONTROL INFLAMMATION AND EXCESS CLOTTING
1.High Dose Intravenous Ascorbic Acid a.3 grams every 6 hours
b.continue for a total of 7 days or until discharged
2.Full Dose Low Molecular Weight Heparina.1 mg/kg subcutaneous injection every 12 hours
b.continue until discharged
3.Intravenous Methylprednisolone
a.60 mg once a day
b.continue for 7 days, then
c.switch to oral prednisone, taper over 6 days
4.Oral Hydroxychloroquine
a.400 mg every 12 hours for one day
b.switch to 200 mg every 12 hours for a total of 4 days
TREATMENT OF LOW OXYGEN
a.If patient has low oxygen saturation on nasal cannula, initiate heated high flow nasal canula
•Do not hesitate to increase flow limits as needed
b. Avoid quick intubation that is based solely on oxygen requirements
•Intubate only if patient’s breathing continues to be labored
c. Utilize “prone positioning” to help improve oxygen saturation
REFERENCES: Vitamin C May Reduce the Duration of Mechanical Ventilation in Critically Ill Patients: a Meta-Regression Analysis. Journal of Intensive Care, 2020.
The Shanghai Consensus on Comprehensive Treatment of Coronavirus Disease:
Children’s Hospital of Chicago — Vitamin C/ Vitamin B1/hydrocortisone, 43 patients – mortality decreased from 28 to 9 percent in 30 days. “American Journal of Respiratory and Critical Care Medicine,” 2020.
Had forgotten about that one.
First heard of it in the book “Life Extension” by Pierce and Shaw, c.1980. Now out of print. Information still available, Life Extension Foundation, www.lef.org
Here is the pdf supplying the information.
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