I don’t know if one night would be python genocide either but remember the python is tropical and the rattlesnake isn’t. Up here, rattlesnakes in their burrows get frozen all the time and still emerge in the late winter or spring. Pythons, as far as I know, aren’t adapted at all to cold conditions.
I’m thinking we just need to let the Cajuns turn them into a new delicacy. Then the snakes will be rare and expensive. I have faith.