Someone better will take his place.
Just like in the Godfather. When a big family goes down, the others scramble for supremacy. But I would imagine that a kingpin will re-emerge.
I remember in the Godfather when Vito “Don” Corleone did not want to get into narcotics because it would hurt the kids. He wanted to stay in gambling, prostitution, and booze.
It might be similar. The old guys were mostly into narcotics, but didn’t get into sex trafficking which has become as or more important than the narcotic trade.