this decision helps the giants like amazon and google, only they can afford to have their business platforms be compliant. Sell stuff yourself out of you home on a basic website? now you need to know if it is taxable and at what rate for 10,000 different locations, that change all the time.
Now to avoid the liability you are gonna have to use one of the big boys storefronts.
You do not need to know anything if you pay about 10 cents per transaction. That does not include filing for the 50 states.