Good luck with that! My gun safe is in the basement and it is weighed down with extra lead inside (both spare ammo stored there for the weight and plain lead). They will have to get the thing open to bring it up stairs, since the steps would not support the weight, even if they had enough people to move it. As for opening it, I built a wall around it, so they will have to take the wall down to get at anything but the door. There is nothing in there worth the effort it would take.
They were selling gun safes at a hardware store near here that were room sized, maybe 12x12, and were meant to build around. So the perps would have to take out at least one wall of the house to get it out, in addition to the roof. That and the crane might attract some attention.