Sure it does. See post #13
The Department of Justice, in a 1974 Opinion Letter, by Assistant Attorney General Scalia, suggested that this clause does not apply to the president: when the word officer is used in the Constitution, it invariably refers to someone other than the President or Vice President.(Emphasis in original.) Scalia relied on an 1878 Supreme Court case concluding that officer of the United States only refers to appointed officials.
I contend that no one knows for sure, since is has never been litigated. I've heard arguments that it does not apply to the President or VP. Trump, nevertheless has contended that it does NOT apply to the president, but he has taken the step to return any money made thru Trump holdings while he is president.