Posted on 01/31/2018 8:27:58 PM PST by Innovative
Activating T cells in tumors eliminated even distant metastases in mice, Stanford researchers found. Lymphoma patients are being recruited to test the technique in a clinical trial.
Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a study by researchers at the Stanford University School of Medicine.
The approach works for many different types of cancers, including those that arise spontaneously, the study found.
(Excerpt) Read more at med.stanford.edu ...
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This is great news, I hope the benefits are transferable to humans. It would be wonderful to consign cancer to the list of “treatable nuisances” ASAP.
“Lymphoma patients are being recruited to test the technique in a clinical trial. “
It is certainly worth exploring it. Sound very promising — a real breakthrough.
Best wishes.
Thanks, and thanks for posting the piece.
Using T cell immune therapy is already being done. The article does not mention what makes the Stanford approach any different? It also does not mention any success with liquid cancers or adenocarcinomas that start in the lining of internal organs? How do T cells attack cancer cells that are just jelly like? Let’s say a woman has had a ruptured appendix and mistook it for a painful period. Then let’s say their ruptured appendix turned into cancer. Now most of their intestines, ovaries, etc. have to be “debulked” (removed). How is T cell therapy going to reverse that? Is this news meant to help a stock prospectus? Or will this just end up yet another dashing of the hopes of victims and their loved ones?
I think that may be addressed in this part:
“Some immunotherapy approaches rely on stimulating the immune system throughout the body. Others target naturally occurring checkpoints that limit the anti-cancer activity of immune cells. Still others, like the CAR T-cell therapy recently approved to treat some types of leukemia and lymphomas, require a patient’s immune cells to be removed from the body and genetically engineered to attack the tumor cells. Many of these approaches have been successful, but they each have downsides — from difficult-to-handle side effects to high-cost and lengthy preparation or treatment times.
“All of these immunotherapy advances are changing medical practice,” Levy said. “Our approach uses a one-time application of very small amounts of two agents to stimulate the immune cells only within the tumor itself. In the mice, we saw amazing, bodywide effects, including the elimination of tumors all over the animal.”
It sounds as if they are on a different tack than current T cell therapy. I don’t think they’d posit it as something new/different if it’s a “yawn, already been done” thing.
But I dunno, I’m certainly no expert. But if anybody can come up with something that helps, good on ‘em.
(Though I can see that the elimination of all types of cancer is probably a long way off.)
AIDs is something I have figured as one disease that will never be cured, though. Managed, yes. Cured, nope.
Well, once again, good news if you’re a mouse....
““When we use these two agents together, we see the elimination of tumors all over the body,” said Ronald Levy, MD, professor of oncology. “This approach bypasses the need to identify tumor-specific immune targets and doesn’t require wholesale activation of the immune system or customization of a patient’s immune cells.”
In case anyone wants to get in touch with the researchers, see above. Prof. Ronald Levy seems to be the main researcher.
big bump!
Remember, this is just a news article on the subject, not a published research paper. You may find they published in a medical journal, where you can find more specifics or even get in touch with the researchers for more info.
This is great but Lymphoma vaccines aren’t something new.
Hope it doesn’t have an I Am Legend type ending
I hope they were listening to Pres. Trump’s speech last night, the part about making experimental treatments available to terminally ill people.
Interesting article you posted from 2010.
Ronald Levy, the main researcher here is one of the authors of the article you listed.
I had a ruptured appendix...and mistook it for a painful period. But only for so long because the pain becomes unbearable and you wind up in the hospital either on your own or someone else will take you.
How is that going to turn into cancer? Just asking.
w00t!
“In case anyone wants to get in touch with the researchers, see above. Prof. Ronald Levy seems to be the main researcher”
And Trump’s “Right to Try” policy would speed up the availability of these new products and procedures for people that have run out of options.
That can happen?
Can you provide links?
Thanks
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