[<1/1,000,000th%]

First marijuana drug approved in the US for anti-nausea in 1985 under the Reagan administration. It's synthetic THC-9. It's the only approved drug in the US where every single person in a clinical trial had adverse effects. It probably couldn't be approved now. But it works.

[NobleFree]

“The poor solubility of Marinol in aqueous solutions and its high first-pass metabolism in the liver account for its poor bioavailability; only 10-20% of an oral dose reaches the systemic circulation. The onset of action is slow; peak plasma concentrations are not attained until two to four hours after dosing. In contrast, inhaled marijuana is rapidly absorbed. In a study comparing THC administered orally, by inhalation, and intravenously, plasma concentration peaked almost instantaneously after both inhalation and intravenous administration; most participants’ peak plasma concentrations after oral administration occurred at 60 or 90 minutes. Variation in individual responses is highest for oral THC and bioavailability is lowest.” - https://www.nap.edu/read/6376/chapter/7#203