I-81 is by far the prettiest driving interstate on the east coast. Well, I can’t speak for whats in NH/VT/ME there may be some nice country there as well, but at least in the south it’s I-81 for scenery.
I-40 from Asheville to Newport, TN is stunning but it’s tough to appreciate the view, full attention needs to be paid to the road. “Watch for falling rocks” adds to the experience, too, lol.
There’s something about the Shenandoah Valley, though. Feels like home although I’ve never lived there personally. Genetic memory? Some ancestors were there prior to the 1760’s.