Eli Lilly Alzheimer’s Drug Fails Trial

WSJ ^ | 11/23 | loftus

[Gay State Conservative]

Last year,while on safari in South Africa,we met a brain researcher from the Karolinska Institute in Stockholm.During the several nights we all had together (we were watching wildlife during the day) he "held court" for a German physician and a German medical student who were with us.Fascinating stuff.He told me,a civilian,that science today knows more about the surface of the moon than about the human brain.

So it must be expected that advances in that area will be hit and miss...even for major drug companies.

[FreedomNotSafety]

Never heard that before. Thanks. I am going to look into that.

[uncbob]

My wife’s family grew up eating fats
Still get Alzheimers

[aimhigh]

The scientists keep aiming for amyloid beta, when it is obviously not the cause. Amyloid beta is the body’s response to the problem, not the cause. When MS mice were injected with amyloid beta, the MS was cured.

[sarasota]

Sugars are also cancer’s favorite food. It helps cancer hijack your nutrition thus speeding their cell’s growth.

[FreedomNotSafety]

But do they eat low carb? I live in area where people never laid off of fat but they also drink the wretched “sweet tea”. The southern style were you have to boil the tea so that it can dissolve all of the sugar. The kids drink Mountain Dew. Having bacon is not enough to offset the biscuits-n-gravey. Lord knows I gave it a try.

[ilovesarah2012]

Have people always developed alzheimers or is it a modern disease? My grandmother was born in 1879 and lived to be 100. She didn’t have alzheimers but did have some confusion near the end of her life.

[Steamburg]

-12 points and counting says it failed. This may well be a buying opportunity.

[Yaelle]

My mom has Alzheimer’s and I am her caregiver. She craves pure sugar like nobody’s business. She will sneak to find anything that smacks of sweet. We have to hide the grain products and even the fruit. It’s insane. She also will eat just about anything. But she just goes nuts over sweets. It’s really tough.

[LS]

“It is appointed once for man to die.”

Really no getting around that.

[Yaelle]

Clearly. Drug research really sucks sometimes. Alzheimer’s needs to be stopped way earlier than that. Amyloid beta isn’t the cause.

[Colinsky]

We’re still probing in the dark about Alzheimer’s. The build-up of plaques and tangles in the brain does not always cause dementia, according to a study released last week.

“Researchers analyzed the brains of eight people who died in their 90s and who had excellent recall until then. Three of the eight brains had the defining amyloid plaques and tau tangles of Alzheimer’s, yet somehow were “immune to [their] effects,” said neurologist Changiz Geula, of Northwestern University Feinberg School of Medicine.

“What’s significant about these findings is that they show there can be high densities of plaques and tangles in the brains of some elderly individuals who are cognitively normal or even superior.”

https://www.statnews.com/2016/11/14/alzheimers-brain-amyloid-plaque/

[momincombatboots]

But did the drugs reduce the build up? If so, then we move on, obviously the cause was wrong. I think it is epigenetics.. tied to either our diet or our physical habits.

[shotgun]

I’m sorry to hear about your mother’s condition, but can I ask what is the problem with giving her sweets?

[lombardwarrior2]

Have you mother checked for candida. Might solve a lot of the problems, maybe even the Alz.

[uncbob]

No they did not eat low carb

[wally_bert]

Thanks for the tip.

[TonyM]

Right, you discovered the cure for Altzhiemer’s, but you put it down somewhere and cannot find it.

[PA Engineer]

Strong links to low-fat diets and Alzheimer’s. I tend to believe that obesity, diabetes, and Alzheimer’s are all linked to low-fat. A minister in the UK health ministry said the UK should apologize for its now debunked and harmful advice to lower fat intake and increase consumption of “fat-free” foods.

Agreed. Low fat and high carbohydrate diets are the primary cause of metabolic syndrome. Metabolic syndrome is the precursor to Type II Diabetes and brain insulin disregulation.

Insulin disregulation is damaging at the cellular level and leaves to increased cysteine and iron binding in the brain. This also results in damage to the Blood Brain Barrier (BBB). Insulin resistance also disrupts the pyruvate cycle.

Alzheimer's is not a disease that occurs over a short period of time, but takes decades of damage before the onset of symptoms. The low fat high carbohydrate diet is the cause of the degenerative metabolic disorder that spans decades.

A better treatment than a simple pill, is to control if not reverse the insulin resistance with a low carbohydrate (VLC) or ketogenic diet. The diet should include median chain fatty acids (MCFAs) with a few supplements that are proven to remove iron and repair the BBB. MCFAs are found in coconut and palm oils. Coconut oil is not strictly and MCFA (60%), however it is shelf stable and provides sufficient nutrition to feed the diseased brain. MCFAs do not require the pyruvate cycle, but move from the stomach to portal vein and the liver. Once in the blood stream, the MCFAs enter the brain within the carnitine shuttle. This is a two step process versus 27 steps in the pyruvate cycle.

Two primary supplements are available and have been shown to stop and reverse some of the damage. One is Pantethine and the other is a special formulation of Curcumin (LongVida) being studied by UCLA. Pantethine is rapidly hydrolyzed (in digestion) to pantothenic acid and Cysteamine. Cysteamine crosses the BBB and binds the excess iron in the brain. Pantothenic acid has been indicated as a BBB repair agent. Curcumin blocks and reduces plaque formation as a host of other inflammatory responses.

We are on the cusp of a rapidly growing epidemic induced by government interference and junk dietary science. Recently our "government science" has doubled down on low fat diets and prescription of Statins (that is an entire different and horrifying subject). This will lead to far worse disease states in the general US population.

[PA Engineer]

Thanks for the info.