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Eli Lilly Alzheimer’s Drug Fails Trial
WSJ ^ | 11/23 | loftus

Posted on 11/23/2016 7:27:10 AM PST by RummyChick

An experimental Eli Lilly & Co. drug failed to significantly help Alzheimer’s disease patients in a closely watched clinical trial, dealing another blow to the pharmaceutical industry’s long quest to find a better treatment for the condition.

The disappointing outcome also may revive doubts about an entire branch of Alzheimer’s research that has dominated the industry’s efforts in the past decade. Lilly and other companies have developed drugs that try to stop the buildup of a sticky protein in the brain known as beta amyloid—believed by many to be the primary culprit in the disease. But none of these drugs has worked in a major patient study, and Lilly’s failure could spur efforts to pursue alternative drug targets.

(Excerpt) Read more at wsj.com ...


TOPICS: News/Current Events
KEYWORDS: alzheimers; alzheimersdrug; pharmaceuticals
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1 posted on 11/23/2016 7:27:10 AM PST by RummyChick
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To: RummyChick

Try CQ10 and flax oil. (So says my neurologist.)


2 posted on 11/23/2016 7:29:06 AM PST by sarasota
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To: RummyChick

Maybe that’s not the culprit.


3 posted on 11/23/2016 7:29:10 AM PST by Sacajaweau
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To: Sacajaweau

I am taking coconut oil pills but actual coconut oil would probably be better.


4 posted on 11/23/2016 7:31:34 AM PST by RummyChick (Trump Train Hobo TM Rummychick. Example - Ryan Romney Kasich. Quit trying to Jump on the Train)
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To: RummyChick

Or at least I think it failed


5 posted on 11/23/2016 7:34:34 AM PST by Emergencyawesome
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To: RummyChick
Who knows.

What we do know is that the human body, despite its extraordinary mending abilities (cuts, broken bones etc), will deteriorate with age. There is no escape.

Some of us are luckier than others. I'm 72 and our family has some good genes.

But for others...my heart aches and I make sure St. Jude gets a piece of my action.

6 posted on 11/23/2016 7:37:57 AM PST by Sacajaweau
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To: sarasota

Krill oil


7 posted on 11/23/2016 7:41:36 AM PST by traderrob6
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To: RummyChick

It’s a nasty disease. Good for Lilly and all pharmas trying to beat this monster. Lilly has spent $3,000,000,000 in thirty years to find if not a cure at least a way to arrest the process.


8 posted on 11/23/2016 7:42:05 AM PST by InvisibleChurch (https://thepurginglutheran.wordpress.com)
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To: RummyChick

Not safe or not effective I wonder. I suppose not effective from the wording. How does it get all the way to human trials before they find it doesn’t work?


9 posted on 11/23/2016 7:45:19 AM PST by ichabod1 (Make America Normal Again)
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To: RummyChick

Strong links to low-fat diets and Alzheimer’s. I tend to believe that obesity, diabetes, and Alzheimer’s are all linked to low-fat. A minister in the UK health ministry said the UK should apologize for its now debunked and harmful advice to lower fat intake and increase consumption of “fat-free” foods.


10 posted on 11/23/2016 7:45:48 AM PST by FreedomNotSafety
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To: RummyChick; Swordmaker; All

How about this:

Alzheimer’s disease - a neurospirochetosis

http://www.freerepublic.com/focus/f-chat/2769347/posts


11 posted on 11/23/2016 7:47:27 AM PST by Auntie Mame (Fear not tomorrow. God is already there.)
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To: RummyChick

http://www.alzheimers.net/6-15-15-effects-of-medical-marijuana-on-alzheimers/

I saw this recently, sounds promising. But who would have ever thought that GOD might just have created the cure.


12 posted on 11/23/2016 7:47:57 AM PST by eyeamok (destruction of government records.)
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To: sarasota

Fish oil...and cut sugar...some call alzheimers Diabetes 3


13 posted on 11/23/2016 7:54:11 AM PST by goodnesswins (Say hello to President Trump)
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To: ichabod1
Not safe or not effective I wonder. I suppose not effective from the wording. How does it get all the way to human trials before they find it doesn’t work?

It was deemed not as efficacious as they defined in their primary clinical end point.

To your question as to how it "gets all the way to human trials..." how else would you determine if it worked, if you didn't test it in humans?

This my FRiend, is one of the reasons pharmaceutical products are more expensive and the prices continues to rise. It costs enormous amounts of money to conduct clinical trials. In these Alzheimer trials, the length of time on the drug to see results was substantial; the diagnostic tests were expensive; and the disease itself is not fully understood. You couldn't just rush into a quick clinical trial without fully understanding the results.

There is other Alzheimer's research ongoing at a number of different companies, but this was definitely a setback for all involved: pharma, patients, caregivers and the medical community.

14 posted on 11/23/2016 7:56:42 AM PST by Lou L (Health "insurance" is NOT the same as health "care")
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To: RummyChick

Did it really fail or is this the Obami Regime’s outgoing damage unfolding ?


15 posted on 11/23/2016 7:58:03 AM PST by George from New England (escaped CT in 2006, now living north of Tampa)
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To: FreedomNotSafety
Strong links to low-fat diets and Alzheimer’s. I tend to believe that obesity, diabetes, and Alzheimer’s are all linked to low-fat. A minister in the UK health ministry said the UK should apologize for its now debunked and harmful advice to lower fat intake and increase consumption of “fat-free” foods.

Yes, FreedomNotSafety -- Low carb High Fat way of eating improves a wide range of "western diseases" and Alzheimers may be one. Some call Alzheimer's "type 3 diabetes". Brain-cell insulin-resistance. Time will tell, in the meantime, I love my LCHF!
16 posted on 11/23/2016 7:58:38 AM PST by Old_Grouch (69 and AARP-free. Monthly FR contributor.)
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To: RummyChick

Did it really fail or is this the Obami Regime’s outgoing damage unfolding ?


17 posted on 11/23/2016 7:59:13 AM PST by George from New England (escaped CT in 2006, now living north of Tampa)
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To: RummyChick

It seems to run in families but I have also seen dementia appear in people who have brain injuries.

My aunt has it but her personality is the same. The greatest problem from the dementia is that she refuses to believe she has it. That causes a lot of problems.

She lost most analytical facilities (i.e. she can’t figure out how to work the date or time or money). She can’t make change. She can’t figure out her meds.


18 posted on 11/23/2016 7:59:48 AM PST by AppyPappy (If you really want to irritate someone, point out something obvious they are trying hard to ignore.)
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To: goodnesswins

I agree, and the book Grain Brain is really helpful. I try to eat blueberries and walnuts everyday, and exercise.
I figure the likelihood of an Alzheimer’s preventative, much less treatment drug in my time span is low.
Anecdotally, my mom has Alzheimer’s and she is a sugar-holic!


19 posted on 11/23/2016 8:10:18 AM PST by GnuThere
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To: sarasota

Also phosphatidyserene, helps the brain clean out. Mackerel contains a lot of phosphatidyserene. You can just get the supplement at a health food store if you hate organ meats and fish.


20 posted on 11/23/2016 8:18:55 AM PST by American in Israel (A wise man's heart directs him to the right, but the foolish mans heart directs him toward the left.)
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