LOL - during the intro mentions that Cruz was born in Canada.
She brought it up again later, specifically referring to birtherism. Cruz's answer was crisp and thorough and included the identity of the first birther: Hillary Rodham Clinton. He closes his answer mentioning the example of Barry Goldwater, who was born in Arizona before it was a state.
She pops the birther question at 26m06s:
https://www.youtube.com/watch?v=Ay1SACxNkD4&t=26m06s
Her next question plays off Goldwater: Does Senator Cruz think it's possible to be too conservative to be elected president? He reminds her that every time the GOP runs establishment moderates, they lose, that the voters prefer the real thing to Democrat Lite, that, as Reagan said, the way to win is to paint in bold colors, not pale pastels. That we must bring together once again the old Reagan coalition.