The Israelis will attack Iran and take out its nuke weapons capability before the Russian-provided (and manned) S-300/SA-10 missiles are operational. And my guess is it will be a combined air, land, & sea operation, with airborne/special forces on the ground. Netanyahu of course can no longer count on the U.S., so they’ll go it alone, as best they can without our air refueling, AWACS/AEW, and logistics support.
All Israel needs to do is irradiate the grounds above and around the facility. One more Chernobyl or Fukushima won’t hurt mama Earth. One or two dirty bombs will do the trick. Easy Peasy.
My guess is that the Saudis and/or the Gulf States will provide the refueling.