“Compare the cruising speed and capacity of the two planes. Osprey wins on capacity,”
Osprey 652 cubic feet. Greyhound 860 cubic feet. And greyhound flies over 500 miles further, faster, with the same load.
The fleet could use a few V22s, but it is no way a replacement for the Greyhound.
Perhaps, if the plane is delivering a cargo of Styrofoam peanuts. But number of bodies or pounds of cargo, the Osprey appears to have the edge. Although speaking of volume, try slinging an oversized load under a Greyhound and let me know how that works out.