That’s a very confusing poster, because the initial impression is bound to be that A.E. Newman is saying “Resist Insanity”, just as he said, “What me Worry?”
The truth is that the reader, or viewer, has always been enticed to identify with this character, just as with, e.g., Beavis and Butthead. The attraction in both cases is the complete freedom of will that they express. I’m down with that.