We were childless when we bought the house and could afford it while cutting back on other things. Then I got a raise and it was comfortable. Then we had a child and started sinking $1,000 per month into childcare/preschool and each subsequent raise has been cancelled out by increasing payroll deductions (first the payroll tax hike and then Obamacare inflating our medical insurance). In August we will be getting most of that $1,000 back as our child enters Kindergarten. It is kind of a moot point now as long as we both keep our jobs between now and August then we can finally start saving some money.
My wife finally quit her job and it had very little financial impact on us. It actually costs a lot of money for both husband and wife to work outside the home.