If you think about it, even were there a way to accelerate a spacecraft to near the speed of light, it seems likely that over interstellar space there would just have to be a solid particle to collide with somewhere on the line between point A and point B - and it would seem that a particle impact at such a speed would be exceedingly dangerous to the spacecraft.
At that point the spacecraft would no longer be a solid
object and would not even be in the same time frame as a
particle. At least that’s how I remember my last trip.