Another report: TXNIP Protein Pathway Discovery Could Point To Possible Diabetes Treatment
Shalev said that for some people, excessive demand on beta cells to produce insulin to counteract elevated blood sugar -- which is what's seen in type 2 diabetes, which accounts for more than 90 percent of all diabetes -- eventually stresses the beta cells, which then lose their ability to make enough insulin to meet demand. This leads to an increase in blood sugar and greater levels of TXNIP production - a vicious cycle that results in even less insulin production and more beta cell death.
Which makes me think that this may not be a path to a cure. Even if we can learn to keep high blood sugar from killing beta cells, in the face of insulin resistance, high blood sugars are still going to be causing plenty of other problems, and hyperinsulinemia causes lots of problems itself.
Seems to me the $64k question is what causes insulin resistance.
Too much sugar in the diet in the first place ?
Even if everything is working correctly blood sugar will peak very high (for a while) if one eats the wrong things. A little too much of this and there we are.