Except the SCOTUS has, with the Obamacare decision, undermined the misinterpretations of the Interstate Commerce Clause, the General Welfare Clause (used by LBJ to create the welfare state), and the Necessary and Proper Clause.
It will take a while for the other shoe to drop, and will depend who the next POTUS is, and whether he appoints conservatives to replace liberals on the court.
I had hopes during the Bush administration. When he was campaigning he professed to support an "original intent" interpretation of the Constitution. Then he send his AG and DOJ lawyers before the USSC to argue to uphold Wickard v Filburn in the Raisch case. It was disgusting.