Nuclear weapon program ender.
Israel would require larger bunker busters to be assured of reaching the appropriate depth, but they don't own those weapons and they don't have the delivery systems (e.g. a B-2 bomber) to use them.
At most, using current weapons and delivery systems - that are not nuclear - Israel can only damage the Iranian complexes. It is important to note it is just not one target but several - there is Natanz, Fordo, Arak, Parchin, and Isfahan ...and even each of those is not one target.
They key here is that they will need US assistance. Without US assistance then the Israelis will be forced to get VERY creative, and even then it will cost them. The good thing though is that no one does 'creative' quite like the Israelis.